用于活体近红外二区（NIR-IIa 和 NIR-IIb）成像的新型小分子荧光团。
Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging.
机构信息
State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Center for Experimental Basic Medical Education, Wuhan 430071, China.
出版信息
Chem Commun (Camb). 2020 Mar 17;56(22):3289-3292. doi: 10.1039/c9cc09865h.
Near-infrared fluorescence imaging in the 1000-1700 nm-wavelength window (NIR-II) has exhibited great potential for deep-tissue bioimaging due to its diminished auto-fluorescence, suppressed photo-scattering, deep penetration, and high spatial and temporal resolutions. Various kinds of inorganic nanomaterials have been extensively developed for NIR-IIa (1300-1400 nm) and NIR-IIb (1500-1700 nm) bioimaging. However, the development of small-molecule NIR-IIa and NIR-IIb fluorophores is still in its infancy. Herein, we designed and synthesized a novel NIR-II organic aggregation-induced emission (AIE) fluorophore (HQL2) with a fluorescence tail extending into the NIR-IIa and NIR-IIb region based on our previous reported skeleton Q4. The encapsulated NIR-II AIE nanoparticles (HQL2 dots) exhibited water solubility and biocompatibility, and high brightness for NIR-IIa and NIR-IIb vascular imaging in vivo, a first for NIR-II AIE dots.
近红外荧光成像在 1000-1700nm 波长窗口（NIR-II）由于其自发荧光减少、光散射抑制、深穿透和高空间及时间分辨率，在深部组织生物成像中显示出巨大的潜力。各种无机纳米材料已被广泛开发用于 NIR-IIa（1300-1400nm）和 NIR-IIb（1500-1700nm）生物成像。然而，小分子 NIR-IIa 和 NIR-IIb 荧光团的发展仍处于起步阶段。在此，我们设计并合成了一种新型的 NIR-II 有机聚集诱导发射（AIE）荧光团（HQL2），其荧光尾部延伸到 NIR-IIa 和 NIR-IIb 区域，基于我们之前报道的骨架 Q4。封装的 NIR-II AIE 纳米粒子（HQL2 点）表现出水溶性和生物相容性，以及在体内进行 NIR-IIa 和 NIR-IIb 血管成像的高亮度，这是 NIR-II AIE 点的首次应用。
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