Chakraborty Debarshi, Gholami Hadi, Sarkar Aritra, Joyce Leo A, Jackson James E, Borhan Babak
Michigan State University, Department of Chemistry East Lansing MI 48824 USA
Department of Process Research and Development, Merck and Co, Inc. Rahway NJ 07065 USA.
Chem Sci. 2020 Dec 7;12(5):1750-1755. doi: 10.1039/d0sc02940h.
A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. Strong coordination of the phosphorus oxide with the Zn-metallo center of the racemic host Zn-MAPOL leads to an induced axial chirality of the host, yielding a strong ECCD signal. A mnemonic is proposed to correlate the asymmetry of the guest molecule with the observed ECCD signal.
本文提出了一种用于绝对立体化学测定不对称磷（V）立体中心的简单手性光学解决方案。氧化磷与外消旋主体Zn-MAPOL的锌金属中心的强配位作用导致主体产生诱导轴向手性，从而产生强烈的电子圆二色（ECCD）信号。本文提出了一种记忆法，用于将客体分子的不对称性与观察到的ECCD信号相关联。
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