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Cell type-specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia.

作者信息

Ueda Junko, Bundo Miki, Nakachi Yutaka, Kasai Kiyoto, Kato Tadafumi, Iwamoto Kazuya

机构信息

Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Saitama, Japan.

出版信息

Psychiatry Clin Neurosci. 2021 Sep;75(9):297-299. doi: 10.1111/pcn.13282. Epub 2021 Jul 22.

DOI:10.1111/pcn.13282
PMID:34164871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8457163/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e63/8457163/f0f992b79240/PCN-75-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e63/8457163/f0f992b79240/PCN-75-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e63/8457163/f0f992b79240/PCN-75-297-g001.jpg

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本文引用的文献

1
Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder.双相障碍患者前额叶皮层启动子处 DNA 甲基化减少和基因特异性神经元过度甲基化。
Mol Psychiatry. 2021 Jul;26(7):3407-3418. doi: 10.1038/s41380-021-01079-0. Epub 2021 Apr 20.
2
Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.综合性分析新生突变为自闭症谱系障碍提供更深入的生物学见解。
Cell Rep. 2018 Jan 16;22(3):734-747. doi: 10.1016/j.celrep.2017.12.074.
3
Gene expression elucidates functional impact of polygenic risk for schizophrenia.
自闭症谱系障碍的遗传学及未来方向。
J Hum Genet. 2023 Mar;68(3):193-197. doi: 10.1038/s10038-022-01076-3. Epub 2022 Aug 30.
4
Comprehensive DNA Methylation Analysis of Human Neuroblastoma Cells Treated With Haloperidol and Risperidone.用氟哌啶醇和利培酮处理的人神经母细胞瘤细胞的全基因组DNA甲基化分析
Front Mol Neurosci. 2021 Dec 6;14:792874. doi: 10.3389/fnmol.2021.792874. eCollection 2021.
基因表达阐明了精神分裂症多基因风险的功能影响。
Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26.
4
Biological insights from 108 schizophrenia-associated genetic loci.108 个精神分裂症相关遗传位点的生物学见解。
Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22.
5
Novel implications of Lingo-1 and its signaling partners in schizophrenia.Lingo-1及其信号转导伙伴在精神分裂症中的新意义。
Transl Psychiatry. 2014 Jan 21;4(1):e348. doi: 10.1038/tp.2013.121.
6
DNA methylation in schizophrenia: progress and challenges of epigenetic studies.精神分裂症中的DNA甲基化:表观遗传学研究的进展与挑战
Genome Med. 2012 Dec 13;4(12):96. doi: 10.1186/gm397. eCollection 2012.
7
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons.神经元表现出独特的 DNA 甲基化特征,与非神经元相比,个体间差异更大。
Genome Res. 2011 May;21(5):688-96. doi: 10.1101/gr.112755.110. Epub 2011 Apr 5.
8
Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis.大规模DNA微阵列分析显示,双相情感障碍或精神分裂症患者死后大脑中线粒体相关基因的表达发生改变。
Hum Mol Genet. 2005 Jan 15;14(2):241-53. doi: 10.1093/hmg/ddi022. Epub 2004 Nov 24.
9
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Neurosci Lett. 2004 Sep 9;367(3):293-7. doi: 10.1016/j.neulet.2004.06.034.
10
Reduction of chromogranin A and B but not C in the cerebrospinal fluid in subjects with schizophrenia.精神分裂症患者脑脊液中嗜铬粒蛋白A和B含量降低,但嗜铬粒蛋白C未降低。
Eur Neuropsychopharmacol. 1999 Jun;9(4):311-5. doi: 10.1016/s0924-977x(98)00042-x.