Vendrell J, Nubiola A, Goday A, Bosch X, Esmatjes E, Gomis R, Vilardell E
Endocrinology and Diabetes Unit, Clinic Hospital, School of Medicine, Barcelona University, Catalonia, Spain.
Diabetes Res. 1988 Mar;7(3):149-51.
Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities. It can be either primary (idiopathic) or secondary, but both forms require a critical temperature between 32-36 degrees C to provoke the crisis. Among the secondary forms, its association with diabetes mellitus is infrequent and its significance is little known. The histological studies have been fundamentally performed in patients with this syndrome affected by thrombocythemia; vascular thrombosis and fibromuscular intimal arteriolar proliferation were the prominent findings not corroborated in patients with the primary form. We studied one patient with acute diabetic neuropathy who developed erythromelalgia. We noted the absence of histopathological lesions, suggesting a disorder in vascular motility regulation favored by the severe neuropathy, without being able to discount a possible immunomediated mechanism. We describe the favourable evolution of the patient after treatment with aspirin and methysergide.
红斑性肢痛症是一种以受影响肢体出现红斑、灼痛和皮肤温度升高为特征的综合征。它可以是原发性（特发性）的，也可以是继发性的，但两种形式都需要32 - 36摄氏度之间的临界温度来引发发作。在继发性形式中，它与糖尿病的关联并不常见，其意义也鲜为人知。组织学研究主要在患有血小板增多症的该综合征患者中进行；血管血栓形成和纤维肌性内膜小动脉增生是主要发现，而原发性形式的患者中未得到证实。我们研究了一名患有急性糖尿病性神经病变并发展为红斑性肢痛症的患者。我们注意到没有组织病理学病变，提示严重神经病变有利于血管运动调节紊乱，同时也不能排除可能的免疫介导机制。我们描述了该患者在接受阿司匹林和麦角新碱治疗后的良好转归。
