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红斑性肢痛症:新理论与新疗法

Erythromelalgia: new theories and new therapies.

作者信息

Cohen J S

机构信息

Department of Psychiatry, University of California, San Diego, USA.

出版信息

J Am Acad Dermatol. 2000 Nov;43(5 Pt 1):841-7. doi: 10.1067/mjd.2000.109301.

DOI:10.1067/mjd.2000.109301
PMID:11050591
Abstract

Erythromelalgia is a rare condition that has remained an enigma diagnostically and therapeutically for decades. It has been assumed that erythromelalgia, which is characterized by hot, red, intensely painful feet or hands, may be the opposite of Raynaud's phenomenon. However, new research suggests that these two disorders are more similar than dissimilar. Erythromelalgia usually follows a chronic, sometimes progressive and disabling course. New evidence suggests that this may not be a disease entity at all, but a syndrome of dysfunctional vascular dynamics; recent studies demonstrate that this dysfunction is reversible in some patients. This review article presents the latest theories and successful treatments for erythromelalgia, and data from a survey of members of The Erythromelalgia Association, which was formed to provide information about erythromelalgia to doctors and patients.

摘要

红斑性肢痛症是一种罕见病症,几十年来在诊断和治疗方面一直是个谜。人们一直认为,以足部或手部发热、发红、剧痛为特征的红斑性肢痛症,可能与雷诺现象相反。然而,新的研究表明,这两种病症的相似之处多于不同之处。红斑性肢痛症通常呈慢性病程,有时会进展并导致残疾。新证据表明,这可能根本不是一种疾病实体,而是一种血管动力学功能失调综合征;最近的研究表明,这种功能失调在一些患者中是可逆的。这篇综述文章介绍了红斑性肢痛症的最新理论和成功治疗方法,以及对红斑性肢痛症协会成员进行调查的数据,该协会的成立旨在为医生和患者提供有关红斑性肢痛症的信息。

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Erythromelalgia: new theories and new therapies.红斑性肢痛症:新理论与新疗法
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Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.与急性糖尿病性神经病变相关的红斑性肢痛症:一种罕见病症。
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Refractory erythromelalgia of the ears: response to mexiletine.难治性耳红肢痛:美西律治疗反应。
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Functional vascular diseases: Raynaud's syndrome, acrocyanosis and erythromelalgia.功能性血管疾病:雷诺综合征、手足发绀症和红斑性肢痛症。
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引用本文的文献

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Comparative Efficacy and Tolerability of Treatments for Erythromelalgia: A Systematic Review.红斑性肢痛症治疗的比较疗效和耐受性:一项系统评价
Medicina (Kaunas). 2025 May 19;61(5):920. doi: 10.3390/medicina61050920.
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A Rare Case of Refractory Erythromelalgia Managed by Botulinum Toxin A.1例肉毒杆菌毒素A治疗难治性红斑性肢痛症的罕见病例。
Indian Dermatol Online J. 2024 Nov 14;16(1):141-142. doi: 10.4103/idoj.idoj_827_23. eCollection 2025 Jan-Feb.
3
Severe Pediatric Erythromelalgia: A Case Report on Multimodal Pain Management and the Role of Regional Anesthesia.
重度小儿红斑性肢痛症:多模式疼痛管理及区域麻醉作用的病例报告
Cureus. 2024 Oct 13;16(10):e71351. doi: 10.7759/cureus.71351. eCollection 2024 Oct.
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Raynaud's Phenomenon: A Current Update on Pathogenesis, Diagnostic Workup, and Treatment.雷诺现象:发病机制、诊断检查及治疗的最新进展
Vasc Specialist Int. 2024 Jul 23;40:26. doi: 10.5758/vsi.240047.
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A novel cause of erythromelalgia due to pseudoephedrine.由伪麻黄碱引起的红斑性肢痛症的一种新病因。
Oxf Med Case Reports. 2024 Apr 25;2024(4):omae037. doi: 10.1093/omcr/omae037. eCollection 2024 Apr.
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A case of erythromelalgia with gastrointestinal dysautonomia treated with immunoglobulin: A case report.1例用免疫球蛋白治疗的伴有胃肠自主神经功能障碍的红斑性肢痛症:病例报告
SAGE Open Med Case Rep. 2023 Nov 20;11:2050313X231213137. doi: 10.1177/2050313X231213137. eCollection 2023.
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Dermatol Pract Concept. 2023 Jul 1;13(3):e2023191. doi: 10.5826/dpc.1303a191.
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Endoscopic lumbar sympathectomy as a treatment option for primary erythromelalgia - case report and review.内镜下腰交感神经切除术作为原发性红斑性肢痛症的一种治疗选择——病例报告及文献复习
J Vasc Bras. 2023 Mar 10;22:e20220095. doi: 10.1590/1677-5449.202200952. eCollection 2023.
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Primary erythromelalgia mainly manifested by hypertensive crisis: A case report and literature review.以高血压危象为主要表现的原发性红斑性肢痛症:一例报告及文献复习
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