Chemical Biology Unit, Institute of Nano Science and Technology, Sector-81, Mohali (SAS Nagar), Knowledge City, Punjab 140306, India.
Chemical Biology Unit, Institute of Nano Science and Technology, Sector-81, Mohali (SAS Nagar), Knowledge City, Punjab 140306, India.
Curr Opin Microbiol. 2021 Oct;63:43-51. doi: 10.1016/j.mib.2021.05.008. Epub 2021 Jun 21.
Bacterial microcompartments represent a modular class of prokaryotic organelles associated with metabolic processes. They harbor a congregation of enzymes that work in cascade within a small, confined volume. These sophisticated nano-engineered crafts of nature offer a tempting paradigm for the fabrication of biosynthetic nanoreactors. Repurposing bacterial microcompartments to develop nanostructures with desired functions requires a careful manipulation in their structural makeup and composition. This calls for a comprehensive understanding of all the interactions of the physical components which frame such molecular architectures. Over recent years, several biophysical techniques have been essential in illuminating the role played by bacterial microcompartments within cells, and have revealed crucial details regarding the morphology, physical properties and functions of their constituent proteins. This has promoted contemplation of ideas for engineering microcompartments inspired biomaterials with novel features and functions.
细菌微室是与代谢过程相关的一类具有模块性的原核细胞器。它们包含了一组在一个小而封闭的空间内级联工作的酶。这些复杂的自然纳米工程结构为生物合成纳米反应器的制造提供了诱人的范例。为了获得具有所需功能的纳米结构，需要对细菌微室的结构组成进行精心的操作。这需要全面了解构成这些分子结构的所有物理组件的相互作用。近年来，几种生物物理技术对于阐明细菌微室在细胞内所起的作用至关重要，并且揭示了其组成蛋白的形态、物理性质和功能的关键细节。这促进了人们对受细菌微室启发的工程生物材料的思考，这些材料具有新颖的特性和功能。
