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细胞周期蛋白依赖性激酶5调节亚基相关蛋白1样蛋白1表达对非转移性鼻咽癌患者生存的影响

Influence of CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Expression on the Survival of Patients with Non-Metastatic Nasopharyngeal Carcinoma.

作者信息

Li Zhanzhan, Zhao Yajie

机构信息

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.

出版信息

Cancer Manag Res. 2021 Jun 17;13:4821-4828. doi: 10.2147/CMAR.S314925. eCollection 2021.

DOI:10.2147/CMAR.S314925
PMID:34168501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8216668/
Abstract

BACKGROUND

The aim of this study was to investigate the influence of CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) expression on the survival of nasopharyngeal carcinoma (NPC) patients.

METHODS

A total of 140 non-metastatic NPC patients were retrospectively analyzed. The expression of CDKAL1 was detected by immunohistochemistry.

RESULTS

The CDKAL1-negative group exhibited better overall survival (OS) according to Kaplan-Meier curve analysis ( = 0.006), with 5-year OS rates for the CDKAL1-negative and -positive groups of 89.7% and 70.2%, respectively. The CDKAL1-negative group also exhibited a tendency toward a better progression-free survival (PFS) rate. Multivariate analysis showed that CDKAL1 expression was independently associated with both OS ( = 0.002) and PFS ( = 0.043).

CONCLUSION

CDKAL1 expression is an independent negative predictor of patient survival in non-metastatic NPC.

摘要

背景

本研究旨在探讨细胞周期蛋白依赖性激酶5调节亚基相关蛋白1样蛋白1（CDKAL1）表达对鼻咽癌（NPC）患者生存的影响。

方法

回顾性分析140例非转移性NPC患者。采用免疫组织化学法检测CDKAL1的表达。

结果

根据Kaplan-Meier曲线分析，CDKAL1阴性组的总生存期（OS）较好（P = 0.006），CDKAL1阴性组和阳性组的5年OS率分别为89.7%和70.2%。CDKAL1阴性组的无进展生存期（PFS）率也有更好的趋势。多因素分析显示，CDKAL1表达与OS（P = 0.002）和PFS（P = 0.043）均独立相关。

结论

CDKAL1表达是非转移性NPC患者生存的独立负性预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/55aa86049f93/CMAR-13-4821-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/686cb58bef7a/CMAR-13-4821-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/eb815787cbe9/CMAR-13-4821-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/55aa86049f93/CMAR-13-4821-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/686cb58bef7a/CMAR-13-4821-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/eb815787cbe9/CMAR-13-4821-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a92/8216668/55aa86049f93/CMAR-13-4821-g0003.jpg

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