Lugaresi A, Montagna P, Gallassi R, Lugaresi E
Institute of Neurology, University of Bologna, Italy.
Eur Neurol. 1988;28(4):208-11. doi: 10.1159/000116268.
Apathy, mood depression and extrapyramidal signs consisting of akinesia, amimia, gait apraxia, slight rigidity and tremor were induced in 10 patients by long-term treatment with flunarizine for trivial complaints. These symptoms suggest a mild antidopaminergic activity of flunarizine. Long-term administration of flunarizine should be avoided particularly in the elderly and in patients with extrapyramidal disorders.
10例患者因长期服用氟桂利嗪治疗轻微病症而出现了冷漠、情绪抑郁以及由运动不能、表情缺失、步态失用、轻度强直和震颤组成的锥体外系体征。这些症状提示氟桂利嗪具有轻度抗多巴胺能活性。应避免长期使用氟桂利嗪，尤其是老年人和患有锥体外系疾病的患者。
