Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.
Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, Colorado, USA.
Vet Comp Oncol. 2021 Sep;19(3):420-427. doi: 10.1111/vco.12744. Epub 2021 Jul 18.
Adoptive cell transfer (ACT) is a burgeoning therapeutic modality within human immuno-oncology. Novel approaches towards ACT are being developed in the pre-clinical setting faster than they can be evaluated in human clinical trials. Many of the therapeutic approaches used in human medicine have already been evaluated to some degree in canine patients. While this form of immunotherapy in veterinary medicine is still in its infancy, as these approaches develop, canine ACT will become a tool for both the veterinary oncologist and the translational researcher. This review details canine ACT trials to date, with attention given to the precedents provided by human oncology.
过继细胞转移(ACT)是人类肿瘤免疫治疗领域中一种新兴的治疗方式。在临床前研究中,ACT 的新方法发展速度快于在人体临床试验中的评估速度。许多在人类医学中使用的治疗方法已经在犬科患者中进行了一定程度的评估。虽然这种形式的免疫疗法在兽医医学中仍处于起步阶段,但随着这些方法的发展,犬科 ACT 将成为兽医肿瘤学家和转化研究人员的工具。本综述详细介绍了迄今为止的犬科 ACT 试验,并关注了人类肿瘤学提供的范例。