2019 - 2020年季节中，有症状的严重急性呼吸综合征冠状病毒2感染风险与流感疫苗接种无关。
Risk of symptomatic severe acute respiratory syndrome coronavirus 2 infection not associated with influenza vaccination in the 2019-2020 season.
作者信息
King Jennifer P, McLean Huong Q, Belongia Edward A
机构信息
Center for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
出版信息
Influenza Other Respir Viruses. 2021 Nov;15(6):697-700. doi: 10.1111/irv.12880. Epub 2021 Jun 25.
Abstract
The association of influenza vaccine and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was assessed by test-negative design using data collected for a study of outpatient COVID-19-like illness with onset dates from June to September 2020. Multivariable logistic regression models examined the association between receipt of 2019-2020 influenza vaccine and PCR-confirmed SARS-CoV-2 with adjustment for potential confounders. Receipt of influenza vaccine during the 2019-2020 influenza season was not associated with increased odds of SARS-CoV-2 infection in adults (aOR 0.83, 95% CI 0.63 to 1.10) or children (aOR 0.92, 95% CI 0.47 to 1.80).
摘要
采用检测阴性设计，利用2020年6月至9月期间收集的门诊COVID-19样疾病研究数据，评估流感疫苗与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染之间的关联。多变量逻辑回归模型检验了2019-2020年流感疫苗接种与PCR确诊的SARS-CoV-2之间的关联，并对潜在混杂因素进行了调整。在2019-2020年流感季节接种流感疫苗与成人（调整后比值比0.83，95%置信区间0.63至1.10）或儿童（调整后比值比0.92，95%置信区间0.47至1.80）感染SARS-CoV-2的几率增加无关。
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