Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Independent statistical Consultant, Kansas City, MO, USA.
Vasc Med. 2021 Dec;26(6):613-623. doi: 10.1177/1358863X211021918. Epub 2021 Jun 25.
The coronavirus disease 2019 (COVID-19) pandemic's impact on vascular procedural volumes and outcomes has not been fully characterized.
Volume and outcome data before (1/2019 - 2/2020), during (3/2020 - 4/2020), and following (5/2020 - 6/2020) the initial pandemic surge were obtained from the Vascular Quality Initiative (VQI). Volume changes were determined using interrupted Poisson time series regression. Adjusted mortality was estimated using multivariable logistic regression.
The final cohort comprised 57,181 patients from 147 US and Canadian sites. Overall procedure volumes fell 35.2% (95% CI 31.9%, 38.4%, < 0.001) during and 19.8% (95% CI 16.8%, 22.9%, < 0.001) following the surge, compared with presurge months. Procedure volumes fell 71.1% for claudication (95% CI 55.6%, 86.4%, < 0.001) and 15.9% for chronic limb-threatening ischemia (CLTI) (95% CI 11.9%, 19.8%, < 0.001) but remained unchanged for acute limb ischemia (ALI) when comparing surge to presurge months. Adjusted mortality was significantly higher among those with claudication (0.5% vs 0.1%; OR 4.38 [95% CI 1.42, 13.5], = 0.01) and ALI (6.4% vs 4.4%; OR 2.63 [95% CI 1.39, 4.98], = 0.003) when comparing postsurge with presurge periods.
The first North American COVID-19 pandemic surge was associated with a significant and sustained decline in both elective and nonelective lower-extremity vascular procedural volumes. When compared with presurge patients, in-hospital mortality increased for those with claudication and ALI following the surge.
2019 年冠状病毒病(COVID-19)大流行对血管程序量和结果的影响尚未完全描述。
从血管质量倡议(VQI)获得了大流行初期激增之前(1/2019-2/2020)、期间(3/2020-4/2020)和之后(5/2020-6/2020)的量和结果数据。使用中断泊松时间序列回归确定体积变化。使用多变量逻辑回归估计调整后的死亡率。
最终队列包括来自美国和加拿大 147 个地点的 57181 名患者。与大流行前几个月相比,手术量在激增期间和之后分别下降了 35.2%(95%CI 31.9%,38.4%,<0.001)和 19.8%(95%CI 16.8%,22.9%,<0.001)。间歇性跛行的手术量下降了 71.1%(95%CI 55.6%,86.4%,<0.001),慢性肢体威胁性缺血(CLTI)的手术量下降了 15.9%(95%CI 11.9%,19.8%,<0.001),但与大流行前几个月相比,急性肢体缺血(ALI)的手术量保持不变。与大流行前相比,间歇性跛行(0.5%比 0.1%;OR 4.38[95%CI 1.42,13.5],=0.01)和 ALI(6.4%比 4.4%;OR 2.63[95%CI 1.39,4.98],=0.003)患者的调整死亡率明显更高。
北美首例 COVID-19 大流行激增与下肢血管择期和非择期手术量的显著和持续下降有关。与大流行前患者相比,激增后间歇性跛行和 ALI 患者的住院死亡率增加。