热潮、失眠和生殖阶段：EPISONO 研究中女性的横断面观察。
Hot flashes, insomnia, and the reproductive stages: a cross-sectional observation of women from the EPISONO study.
机构信息
Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, Brazil.
出版信息
J Clin Sleep Med. 2021 Nov 1;17(11):2257-2267. doi: 10.5664/jcsm.9432.
STUDY OBJECTIVES
To investigate the association of hot flashes and insomnia in women in premenopause and postmenopause.
METHODS
The study was performed using data from the São Paulo Epidemiological Sleep Study. Women in premenopause were classified as having regular menstrual cycles, being anovulatory, or using hormonal contraceptives. Women in menopause were classified as being in perimenopause, early postmenopause, or late postmenopause. Women reporting frequent insomnia symptoms and relevant daytime complaints were classified as having insomnia disorder. Polysomnography alterations suggestive of insomnia were also identified.
RESULTS
The frequency of hot flashes was 42% among women in postmenopause (mainly in early postmenopause) and 9% among women in premenopause (mainly anovulatory; < .01). Approximately 18.7% had insomnia disorder, 48% had isolated insomnia symptoms, and 32.4% had polysomnography alterations. Comparing women in menopause with those in premenopause, the diagnosis of insomnia was similar (premenopause: 18.9% vs menopause: 17.5%), but women in menopause had more frequent isolated insomnia symptoms (premenopause: 43.9% vs menopause: 55.9%; = .02) and polysomnography correlates of insomnia (premenopause: 26.5% vs menopause: 42.6%; < .01). Hot flashes were more frequent among women with insomnia disorders (25.5%) and with isolated insomnia symptoms (23.0%) when compared with good sleepers (12.6%) in the entire sample ( = .01). Among women in late menopause, the prevalence of hot flashes was higher in both women with insomnia disorders (42.1%) and with isolated insomnia symptoms (37.5%) when compared with women who were good sleepers (14.3%; = .05).
CONCLUSIONS
Hot flashes are associated with insomnia and polysomnography alterations suggestive of insomnia. The prevalence of hot flashes among women with insomnia disorder is especially high among women in late postmenopause.
CITATION
Hachul H, Castro LS, Bezerra AG, et al. Hot flashes, insomnia, and the reproductive stages: a cross-sectional observation of women from the EPISONO study. 2021;17(11):2257-2267.
研究目的
探讨围绝经期和绝经后女性热潮红与失眠的关系。
方法
本研究使用了圣保罗流行病学睡眠研究的数据。围绝经期女性分为月经周期规律、无排卵或使用激素避孕药的人群。绝经后女性分为围绝经期、绝经早期和绝经晚期。报告经常出现失眠症状和相关日间抱怨的女性被归类为患有失眠障碍。还确定了提示失眠的多导睡眠图改变。
结果
绝经后女性热潮红的频率为 42%（主要为绝经早期），围绝经期女性为 9%（主要为无排卵；<.01）。约 18.7%有失眠障碍，48%有孤立性失眠症状，32.4%有多导睡眠图改变。与围绝经期女性相比，绝经后女性的失眠诊断相似（围绝经期：18.9% vs 绝经后：17.5%），但绝经后女性孤立性失眠症状更为频繁（围绝经期：43.9% vs 绝经后：55.9%；<.02），多导睡眠图与失眠相关的指标也更多（围绝经期：26.5% vs 绝经后：42.6%；<.01）。在整个样本中，与睡眠良好者（12.6%）相比，失眠障碍者（25.5%）和孤立性失眠症状者（23.0%）的热潮红更为常见（ =.01）。在绝经后期女性中，与睡眠良好者（14.3%）相比，失眠障碍者（42.1%）和孤立性失眠症状者（37.5%）的热潮红发生率更高（ =.05）。
结论
热潮红与失眠和提示失眠的多导睡眠图改变有关。在失眠障碍女性中，尤其是在绝经后期女性中，热潮红的发生率尤其高。
引文
Hachul H, Castro LS, Bezerra AG, et al. Hot flashes, insomnia, and the reproductive stages: a cross-sectional observation of women from the EPISONO study. 2021;17(11):2257-2267.
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