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Images: unilateral rhinorrhea in a patient starting autotitrating positive airway pressure therapy for obstructive sleep apnea.图像：一位开始自动滴定正压通气治疗阻塞性睡眠呼吸暂停的患者出现单侧鼻漏。
J Clin Sleep Med. 2021 Nov 1;17(11):2345-2347. doi: 10.5664/jcsm.9470.
2
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本文引用的文献

1
International Consensus Statement: Spontaneous Cerebrospinal Fluid Rhinorrhea.国际共识声明：自发性脑脊液鼻漏
Int Forum Allergy Rhinol. 2021 Apr;11(4):794-803. doi: 10.1002/alr.22704. Epub 2020 Oct 25.
2
Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea.阻塞性睡眠呼吸暂停持续气道正压通气治疗开始后出现的自发性脑脊液鼻漏和吸入性肺炎。
Respirol Case Rep. 2019 May 20;7(6):e00435. doi: 10.1002/rcr2.435. eCollection 2019 Aug.
3
Iatrogenic Nontraumatic CPAP-Induced Pneumocephalus in a Patient With Meningitis.脑膜炎患者因医源性非创伤性 CPAP 导致的气颅。
J Clin Sleep Med. 2019 May 15;15(5):781-783. doi: 10.5664/jcsm.7776.
4
Beta-2 transferrin is detectable for 14 days whether refrigerated or stored at room temperature.β-2 转铁蛋白在冷藏或室温下均可检测到 14 天。
Int Forum Allergy Rhinol. 2018 Sep;8(9):1052-1055. doi: 10.1002/alr.22136. Epub 2018 May 3.
5
Association Between Obstructive Sleep Apnea and Spontaneous Cerebrospinal Fluid Leaks: A Systematic Review and Meta-analysis.阻塞性睡眠呼吸暂停与自发性脑脊液漏之间的关联：一项系统评价和荟萃分析。
JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):733-8. doi: 10.1001/jamaoto.2015.1128.
6
Predictors of long-term adherence to continuous positive airway pressure therapy in patients with obstructive sleep apnea and cardiovascular disease in the SAVE study.SAVE研究中阻塞性睡眠呼吸暂停合并心血管疾病患者长期坚持持续气道正压通气治疗的预测因素
Sleep. 2013 Dec 1;36(12):1929-37. doi: 10.5665/sleep.3232.
7
Spontaneous cerebrospinal fluid leak repair: a five-year prospective evaluation.自发性脑脊液漏修复：五年前瞻性评估。
Laryngoscope. 2014 Jan;124(1):70-5. doi: 10.1002/lary.24160. Epub 2013 Jun 20.
8
Cerebrospinal fluid leak associated with nasal continuous positive airway pressure treatment for obstructive sleep apnoea.与阻塞性睡眠呼吸暂停鼻腔持续气道正压通气治疗相关的脑脊液漏
BMJ Case Rep. 2010 Sep 7;2010:bcr0120102659. doi: 10.1136/bcr.01.2010.2659.
9
The utility of intrathecal fluorescein in cerebrospinal fluid leak repair.鞘内荧光素在脑脊液漏修复中的应用。
Otolaryngol Head Neck Surg. 2010 Nov;143(5):626-32. doi: 10.1016/j.otohns.2010.07.011.
10
Response of cerebrospinal fluid pressure to continuous positive airway pressure in volunteers.
Anesth Analg. 1994 Jan;78(1):54-7.

图像：一位开始自动滴定正压通气治疗阻塞性睡眠呼吸暂停的患者出现单侧鼻漏。

Images: unilateral rhinorrhea in a patient starting autotitrating positive airway pressure therapy for obstructive sleep apnea.

机构信息

Henry Ford Sleep Disorders Center, Henry Ford Health System, Detroit, Michigan.

Department of Otolaryngology, Henry Ford Hospital, Detroit, Michigan.

出版信息

J Clin Sleep Med. 2021 Nov 1;17(11):2345-2347. doi: 10.5664/jcsm.9470.

DOI:10.5664/jcsm.9470
PMID:34170244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8636357/
Abstract

UNLABELLED

We report a case of a 65-year-old obese female who developed a unilateral nasal cerebrospinal fluid leak after starting autotitrating positive airway pressure therapy for obstructive sleep apnea. The cerebrospinal fluid leak was confirmed by β-2 transferrin testing of the nasal fluid, as well as by identification of the leak through the anterior cribriform plate after administration of intrathecal fluorescein. The cerebrospinal fluid leak was successfully repaired endoscopically, and autotitrating positive airway pressure was reinitiated 1 month postoperatively.

CITATION

Khan O, Craig JR, Begum J, Skiba V. Images: unilateral rhinorrhea in a patient starting autotitrating positive airway pressure therapy for obstructive sleep apnea. . 2021;17(11):2345-2347.

摘要

病例报告

一位 65 岁肥胖女性，在开始使用自动滴定正压通气治疗阻塞性睡眠呼吸暂停后，出现单侧鼻脑脊液漏。通过鼻液 β-2 转铁蛋白检测以及在椎管内荧光素给药后通过前筛板确认漏口，证实了脑脊液漏。通过内镜成功修复了脑脊液漏，术后 1 个月重新开始使用自动滴定正压通气。

参考文献

Khan O, Craig JR, Begum J, Skiba V. 图像：开始自动滴定正压通气治疗阻塞性睡眠呼吸暂停的患者单侧鼻漏。. 2021;17(11):2345-2347.