Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Selangor, Malaysia.
Dermatology Unit, Department of Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Am J Case Rep. 2021 Jun 25;22:e932320. doi: 10.12659/AJCR.932320.
BACKGROUND Trichoblastoma is a rare, benign, cutaneous adnexal neoplasm arising from rudimentary hair follicles. The incidence and prevalence in the general population is unknown. However, most cases occur in adults aged 40 years and older. CASE REPORT A 62-year-old woman presented to our primary care clinic for a hypertension and diabetes followup visit. The doctor, who had never seen the patient before, noticed several small lumps over the patient's eyebrows. After she removed her headscarf and face mask for a thorough examination, numerous skin-colored papules and nodules were seen on her nose, nasal bridge, forehead, and around her eyebrows. She was referred to a dermatologist, and a skin biopsy showed well-circumscribed dermal nests of basaloid cells, with peripheral palisading, and keratin horn cysts surrounded by dense fibrous stroma. These features were consistent with trichoblastoma. She was then referred to a plastic surgeon to discuss further management options. The patient finally chose laser ablation as she was fearful of the other more invasive surgical options. CONCLUSIONS This is a very rare case of extensive facial trichoblastoma. It highlights the need for clinicians to ensure optimal exposure when examining patients. It also highlights the role of biopsies for skin lesions of uncertain etiology. In this case, it helped to rule out basal cell carcinoma, which can be a more locally destructive condition than trichoblastoma. This case also serves as a reminder about the need for ongoing review and referral for further management for conditions for which previous treatment was unsuccessful.
毛母质瘤是一种罕见的良性皮肤附属器肿瘤,来源于原始毛囊。其在普通人群中的发病率和患病率尚不清楚。然而,大多数病例发生在 40 岁及以上的成年人中。
一名 62 岁女性因高血压和糖尿病随访就诊于我们的初级保健诊所。此前从未见过该患者的医生注意到患者眉毛上有几个小结节。在她摘下头巾和口罩进行彻底检查后,发现她的鼻子、鼻梁、额头和眉毛周围有许多肤色丘疹和结节。她被转介给皮肤科医生,皮肤活检显示边界清楚的真皮巢状基底细胞,周围有栅栏状排列,角化角囊肿被致密纤维基质包围。这些特征与毛母质瘤一致。然后她被转介给整形外科医生,以讨论进一步的治疗方案。患者最终选择激光消融术,因为她害怕其他更具侵入性的手术选择。
这是一例非常罕见的广泛面部毛母质瘤病例。它强调了临床医生在检查患者时确保最佳暴露的必要性。它还强调了活检在病因不明的皮肤病变中的作用。在本例中,它有助于排除基底细胞癌,基底细胞癌比毛母质瘤更具有局部破坏性。该病例还提醒人们需要对以前治疗不成功的疾病进行持续复查和转介以进行进一步治疗。