硝苯地平，其对正常血压大鼠和自发性高血压大鼠（SHR）组织中心脏、血管、骨骼肌及血液中阳离子浓度的作用。

Nifedipine, its action on the cationic concentrations in heart, vessels, skeletal muscle and blood in tissues of normotensive and spontaneously hypertensive rats (SHR).

Boeckh Haebisch E M

Department of Pharmacology, University of São Paulo, Brasil.

Gen Pharmacol. 1988;19(3):407-16. doi: 10.1016/0306-3623(88)90038-9.

Abstract

The cationic tissue distribution, obtained by atomic absorption spectrophotometry, was different in normotensive (Wistar) and spontaneously hypertensive male rats (SHR). 2. In both groups, nifedipine (4.2 mg/100 g body wt, by gastric intubation, during 10 days) altered the cationic composition mainly in the aorta, atria and in SHR also in the vein. 3. In normotensive Wistar rats (NWR), nifedipine provoked a higher concentration of divalent cations (Ca2+, Mg2+ and Zn2+) in the ascending part of the aorta and reduced the monovalent (Na+) concentration in the aorta, vein and skeletal muscle. 4. In spontaneously hypertensive rats (SHR) the pathognomonic higher cationic concentrations in the aorta, right atrium and vein are significantly (P less than 0.05) reduced after nifedipine treatment.

摘要

通过原子吸收分光光度法获得的阳离子组织分布，在正常血压的（Wistar）雄性大鼠和自发性高血压雄性大鼠（SHR）中有所不同。2. 在两组中，硝苯地平（4.2毫克/100克体重，经胃插管，持续10天）主要改变了主动脉、心房的阳离子组成，在SHR中还改变了静脉的阳离子组成。3. 在正常血压的Wistar大鼠（NWR）中，硝苯地平使主动脉升部中二价阳离子（Ca2+、Mg2+和Zn2+）浓度升高，并降低了主动脉、静脉和骨骼肌中的一价（Na+）浓度。4. 在自发性高血压大鼠（SHR）中，硝苯地平治疗后，主动脉、右心房和静脉中典型的较高阳离子浓度显著（P小于0.05）降低。