Ishii H, Itoh K, Nose T
Eur J Pharmacol. 1980 May 30;64(1):21-9. doi: 10.1016/0014-2999(80)90365-9.
Antihypertensive effects of nifedipine and hydralazine were investigated in normotensive rats, spontaneously hypertensive rats (SHR), DOCA-NaCl hypertensive rats and renal hypertensive rats all in a conscious state. The blood pressure fall after nifedipine 5 mg/kg p.o. was 22% of the initial value in normotensive rats, 49% in SHR, 53% in DOCA-NaCl hypertensive rats and 44% in renal hypertensive rats. Hydralazine in the same dose decreased the blood pressure by 40% in normotensive rats, 52% in SHR, 33% in DOCA-NaCl hypertensive rats and 54% in renal hypertensive rats. The selective action of nifedipine in hypertensive rats in contrast to normotensive rats seemed to be attributable to the different affinity for calcium ion of vascular smooth muscle of hypertensive rats as compared with that of normotensive rats. Also, the heart rate of hypertensive rats or normotensive rats was increased with nifedipine but less than with hydralazine.
在清醒状态下，对正常血压大鼠、自发性高血压大鼠（SHR）、去氧皮质酮-盐性高血压大鼠和肾性高血压大鼠研究了硝苯地平和肼屈嗪的降压作用。口服5mg/kg硝苯地平后，正常血压大鼠的血压下降幅度为初始值的22%，SHR为49%，去氧皮质酮-盐性高血压大鼠为53%，肾性高血压大鼠为44%。相同剂量的肼屈嗪使正常血压大鼠血压下降40%，SHR下降52%，去氧皮质酮-盐性高血压大鼠下降33%，肾性高血压大鼠下降54%。与正常血压大鼠相比，硝苯地平对高血压大鼠的选择性作用似乎归因于高血压大鼠血管平滑肌与正常血压大鼠血管平滑肌对钙离子的亲和力不同。此外，硝苯地平可使高血压大鼠或正常血压大鼠的心率增加，但增幅小于肼屈嗪。
