Sahlin K
Department of Zoology, University of Stockholm, Sweden.
Gen Comp Endocrinol. 1988 Jun;70(3):436-41. doi: 10.1016/0016-6480(88)90119-0.
Gastrin/CCK-like immunoreactivity was demonstrated in a specific group of epithelial cells in Hatschek's groove. Positive reactions were obtained with antisera directed against the C-terminal amino acid sequence common to mammalian CCK and gastrin, but not with antisera against the midportions of these hormones. No immunoreactivity was obtained with antisera against peptides from hypophysis, neuroendocrine peptides in the gastrointestinal tract, islet hormones, calcitonin, NSE, and S-100. The function of the gastrin/CCK-like peptide found in Hatschek's groove is discussed.
在哈氏沟的一组特定上皮细胞中证实了胃泌素/胆囊收缩素样免疫反应性。用针对哺乳动物胆囊收缩素和胃泌素共有的C末端氨基酸序列的抗血清可获得阳性反应，但用针对这些激素中部的抗血清则未获得阳性反应。用针对垂体肽、胃肠道神经内分泌肽、胰岛激素、降钙素、神经元特异性烯醇化酶和S-100的抗血清未获得免疫反应性。讨论了在哈氏沟中发现的胃泌素/胆囊收缩素样肽的功能。
