Ridolfi R L, Lieberman P H, Erlandson R A, Moore O S
Am J Surg Pathol. 1977 Mar;1(1):43-53.
Schneiderian papillomas are tumors involving the nasal cavity and paranasal sinuses that tend to recur. A long-term clinical follow-up of 30 patients revealed histologically confirmed recurrences in 20 of the 30 patients (67%) and probable recurrences in two additional patients (combined recurrence percentage 73%). Recurrences were most frequent within 1-2 years following primary thrapy and were generally more frequent in patients with more extensive disease and involvement of paranasal sinuses. Histologic features were not helpful in predicting recurrence. One patient in the study (1/30 = 3%) developed a carcinoma at the site of a histologically confirmed benign Schneiderian papilloma after four recurrences over a period of 9 years. No patients died from the tumor. Twenty patients were alive and free of disease at last follow-up; four patients died of unrelated causes and without evidence of disease; four patients are alive with evidence of disease; and two patients died with disease but of unrelated causes. These tumors often pursue a relentless local course requiring multiple surgical excisions but are rarely responsible for death of the patient and seldon undergo a malignant "transformation" (less than 5%).
内翻性乳头状瘤是累及鼻腔和鼻窦的肿瘤，容易复发。对30例患者进行的长期临床随访显示，30例患者中有20例（67%）经组织学证实复发，另有2例可能复发（总复发率73%）。复发最常发生在初次治疗后的1 - 2年内，在疾病范围更广且累及鼻窦的患者中通常更频繁。组织学特征对预测复发并无帮助。该研究中的1例患者（1/30 = 3%）在9年中复发4次后，在组织学证实为良性的内翻性乳头状瘤部位发生了癌变。没有患者死于该肿瘤。最后一次随访时，20例患者存活且无疾病；4例患者死于无关原因且无疾病证据；4例患者存活但有疾病证据；2例患者死于疾病但为无关原因。这些肿瘤通常会持续局部进展，需要多次手术切除，但很少导致患者死亡，也很少发生恶性“转化”（不到5%）。
