Institute of Chemistry, University of Campinas, Josué de, Castro, 10384-612, São Paulo, Brazil.
Chem Rec. 2021 Oct;21(10):2688-2701. doi: 10.1002/tcr.202100149. Epub 2021 Jun 26.
The enantioselective palladium-catalyzed Heck arylation of olefins using arenediazonium salts is one of the last features in the evolution of a synthetic method known as the Heck-Matsuda reaction. This personal account highlights the development of the enantioselective Heck-Matsuda reaction in its initial stages, the challenges faced along the way, and the interesting findings that opened new synthetic opportunities, mainly from our laboratory, featuring the Heck-Matsuda reaction as a central player in the synthesis of bioactive and functional molecules.
手性钯催化烯烃与重氮盐的 Heck 芳基化反应是被称为 Heck-Matsuda 反应的合成方法发展的最新特征之一。本个人述评强调了最初阶段的对映选择性 Heck-Matsuda 反应的发展，以及在发展过程中面临的挑战和有趣的发现，这些发现为新的合成机会开辟了道路，主要来自我们实验室，其中 Heck-Matsuda 反应是生物活性和功能分子合成的核心。
