Papathanasiou Ioanna, Anastasopoulou Lydia, Tsezou Aspasia
Department of Biology, University of Thessaly, Faculty of Medicine, Larisa, Greece; Department of Cytogenetics and Molecular Genetics, University of Thessaly, Faculty of Medicine, Larisa, Greece.
Department of Trauma, Hand and Reconstructive Surgery, University Hospital Giessen, 35392 Giessen, Germany.
Bone. 2021 Nov;152:116076. doi: 10.1016/j.bone.2021.116076. Epub 2021 Jun 24.
Cholesterol homeostasis plays a significant role in skeletal development and the dysregulation of cholesterol-related mechanism has been shown to be involved in the development of cartilage diseases including osteoarthritis (OA). Epidemiological studies have shown an association between elevated serum cholesterol levels and OA. Furthermore, abnormal lipid accumulation in chondrocytes as a result of abnormal regulation of cholesterol homeostasis has been demonstrated to be involved in the development of OA. Although, many in vivo and in vitro studies support the connection between cholesterol and cartilage degradation, the mechanisms underlying the complex interactions between lipid metabolism, especially HDL cholesterol metabolism, and OA remain unclear. The current review aims to address this problem and focuses on key molecular players of the HDL metabolism pathway and their role in ΟΑ pathogenesis. Understanding the complexity of biological processes implicated in OA pathogenesis, such as cholesterol metabolism, may lead to new targets for drug therapy of OA patients.
胆固醇稳态在骨骼发育中起重要作用，并且已表明胆固醇相关机制的失调与包括骨关节炎（OA）在内的软骨疾病的发展有关。流行病学研究表明血清胆固醇水平升高与OA之间存在关联。此外，由于胆固醇稳态调节异常导致软骨细胞中脂质异常积累，已被证明与OA的发展有关。尽管许多体内和体外研究支持胆固醇与软骨降解之间的联系，但脂质代谢，尤其是高密度脂蛋白胆固醇代谢与OA之间复杂相互作用的潜在机制仍不清楚。本综述旨在解决这一问题，并聚焦于高密度脂蛋白代谢途径的关键分子参与者及其在OA发病机制中的作用。了解OA发病机制中涉及的生物过程的复杂性，如胆固醇代谢，可能会为OA患者的药物治疗带来新的靶点。
