Zheng Lin, Ye Zi-Yu, Ma Jun-Ji
Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China.
World J Gastroenterol. 2025 Jan 7;31(1):99960. doi: 10.3748/wjg.v31.i1.99960.
Surgical intervention is currently the primary treatment for hepatolithiasis; however, some patients still experience residual stones and high recurrence rates after surgery. Cholesterol metabolism seems to play an important role in hepatolithiasis pathogenesis. A high cholesterol diet is one of the significant reasons for the increasing incidence of hepatolithiasis. Therefore, regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after surgery. Reducing dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating hepatolithiasis. This article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis, as well as food intake and targeted therapeutic drugs.
手术干预是目前肝内胆管结石的主要治疗方法；然而，一些患者术后仍会出现残余结石且复发率较高。胆固醇代谢似乎在肝内胆管结石的发病机制中起重要作用。高胆固醇饮食是肝内胆管结石发病率上升的重要原因之一。因此，规律饮食和适当的医学干预是预防肝内胆管结石和降低术后复发率的关键措施。降低饮食中的胆固醇以及使用能增加胆固醇结石溶解度的药物是治疗肝内胆管结石的关键治疗方法。本文讨论了与肝内胆管结石发病机制相关的胆固醇代谢途径，以及食物摄入和靶向治疗药物。
