Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
Trends Mol Med. 2021 Sep;27(9):895-906. doi: 10.1016/j.molmed.2021.06.002. Epub 2021 Jun 7.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also includes a post-coronavirus disease 2019 (COVID-19) syndrome ('long COVID') with features that can follow other acute infectious diseases and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here we summarize what is known about the pathogenesis of ME/CFS and of 'acute' COVID-19, and we speculate that the pathogenesis of post-COVID-19 syndrome in some people may be similar to that of ME/CFS. We propose molecular mechanisms that might explain the fatigue and related symptoms in both illnesses, and we suggest a research agenda for both ME/CFS and post-COVID-19 syndrome.
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 可引起慢性和急性疾病。SARS-CoV-2 感染的后急性后遗症 (PASC) 包括肺部、心脏、肾脏和大脑损伤，可能产生各种症状。PASC 还包括一种 2019 年冠状病毒病 (COVID-19) 后综合征（“长新冠”），其特征可跟随其他急性传染病和肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS)。在这里，我们总结了已知的 ME/CFS 和“急性”COVID-19 的发病机制，并推测有些人的 COVID-19 后综合征的发病机制可能与 ME/CFS 相似。我们提出了可能解释两种疾病疲劳和相关症状的分子机制，并为 ME/CFS 和 COVID-19 后综合征提出了一个研究议程。
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