Jason Leonard A, Natelson Benjamin H, Bonilla Hector, Sherif Zaki A, Vernon Suzanne D, Gutierrez Monica Verduzco, O'Brien Lisa, Taylor Emily
DePaul University, USA.
Icahn School of Medicine at Mount Sina, USA.
Brain Behav Immun Integr. 2023 Dec;4. doi: 10.1016/j.bbii.2023.100022. Epub 2023 Sep 7.
Four decades of research in the field of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have yielded lessons that may be instructive for those devising criteria to better comprehend Post-Acute Sequelae of SARS CoV-2 Infection (PASC) and Long COVID. For instance, substantial effort has been devoted to defining classification systems, operationalizing methods, and developing instruments with adequate reliability and validity in the ME/CFS field. The current article provides guidelines for developing a case definition for Long COVID and discusses the significance of psychometric issues and criterion variance, including how to specify symptoms, and develop thresholds, subtypes, and exclusionary conditions. ME/CFS research could enhance our knowledge of Long COVID pathophysiology, early diagnosis, prognosis, and the identification of effective treatments.
在肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）领域长达四十年的研究中获得的经验教训，可能会对那些制定标准以更好理解新冠病毒2感染后急性后遗症（PASC）和长期新冠的人有所启发。例如，在ME/CFS领域，人们投入了大量精力来定义分类系统、实施方法以及开发具有足够可靠性和有效性的工具。本文提供了制定长期新冠病例定义的指南，并讨论了心理测量问题和标准差异的重要性，包括如何明确症状、设定阈值、划分亚型以及确定排除条件。ME/CFS研究可以增进我们对长期新冠的病理生理学、早期诊断、预后以及有效治疗方法识别的了解。
