关于蒜曲霉中asperlicin的生物合成及类似物的定向生物合成
On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
作者信息
Houck D R, Ondeyka J, Zink D L, Inamine E, Goetz M A, Hensens O D
机构信息
Merck & Co., Inc., Rahway, New Jersey 07065-0900.
出版信息
J Antibiot (Tokyo). 1988 Jul;41(7):882-91. doi: 10.7164/antibiotics.41.882.
PMID:3417563
Abstract
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that asperlicin is biosynthesized from tryptophan, anthranilate and leucine. The resting cell system was used also to prepare 25 asperlicin analogs via directed biosynthesis in presence of analogs of tryptophan and leucine.
摘要
用14C标记的氨基酸喂养洋葱曲霉的静止细胞，有力地支持了如下直观假设：asperlicin是由色氨酸、邻氨基苯甲酸和亮氨酸生物合成的。静止细胞系统还用于在色氨酸和亮氨酸类似物存在的情况下，通过定向生物合成制备25种asperlicin类似物。
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