Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Cell Biochem Biophys. 2021 Sep;79(3):449-459. doi: 10.1007/s12013-021-01012-w. Epub 2021 Jun 27.
Acute inflammation in the lung is essential for host defense against pathogens and other injuries but chronic or excessive inflammation can contribute to several common respiratory diseases. In health, the inflammatory response is controlled by several cellular and molecular mechanisms. In addition to anti-inflammatory processes, there are non-phlogistic pro-resolving mechanisms that are engaged to promote the resolution of inflammation and a return to homeostasis. Defects in the production or actions of specialized pro-resolving mediators are associated with diseases characterized by excess or chronic inflammation. In this article, we review cellular and biochemical mechanisms for specialized pro-resolving mediators in health and in sepsis and the acute respiratory distress syndrome as examples of unrestrained inflammatory responses that result in life-threatening pathology. We are honored to contribute to this special edition of the Journal to help celebrate Professor Viswanathan Natarajan's contributions to our understanding of lipid-derived mediators and metabolism in lung cell responses to inflammatory, infectious, or mechanical insults; his foundational discoveries in cell biochemistry and biophysics are continuing to catalyze further advances by the field to uncover the mechanistic underpinnings of important human diseases.
肺部的急性炎症对于宿主防御病原体和其他损伤至关重要，但慢性或过度的炎症可能导致几种常见的呼吸道疾病。在健康状态下，炎症反应受到多种细胞和分子机制的控制。除了抗炎过程，还有非炎症性促解决的机制被激活，以促进炎症的消退和恢复到平衡状态。专门的促解决介质的产生或作用缺陷与以过度或慢性炎症为特征的疾病有关。在本文中，我们综述了专门的促解决介质在健康和脓毒症以及急性呼吸窘迫综合征中的细胞和生化机制，这些疾病的炎症反应不受控制，导致危及生命的病理。我们很荣幸为本期杂志做出贡献，以帮助庆祝 Viswanathan Natarajan 教授对我们理解肺部细胞对炎症、感染或机械损伤的脂质衍生介质和代谢的贡献；他在细胞生物化学和生物物理学方面的基础发现继续推动该领域的进一步进展，以揭示重要人类疾病的机制基础。
