羟氯喹对血脂水平的影响：系统评价和荟萃分析。

Effect of Hydroxychloroquine on Lipid Levels: A Systematic Review and Metaanalysis.

机构信息

Unidad de Investigacion Biomedica, Delegacion Durango, Instituto Mexicano del Seguro Social, CDMX, Mexico.

Department of Orthopedics and Traumatology, Hospital Universitario "Dr. Jose E. Gonzalez", Facultad de Medicina, Universidad Autonoma de Nuevo León, Monterrey, NL, Mexico.

出版信息

Curr Pharm Des. 2021;27(40):4133-4139. doi: 10.2174/1381612827666210625162612.

DOI:10.2174/1381612827666210625162612

PMID:34176459

Abstract

BACKGROUND

It has been suggested that hydroxychloroquine may have positive effects on LDL-C, HDL-C, and triglyceride levels; however, the hypolipidemic activities of this drug are still uncertain.

OBJECTIVE

The aim of this meta-analysis of randomized controlled trials was to explore the effect of hydroxychloroquine on circulating lipid concentrations.

METHODS

Randomized controlled trials examining the impact of hydroxychloroquine on lipid parameters were searched in PubMed, Web of Science, Scopus, and Google Scholar databases. Meta-analysis was performed using a random-effects model and sensitivity analysis through the leave one-out method.

RESULTS

Meta-analysis showed that patients receiving hydroxychloroquine therapy significantly decreased total cholesterol (WMD: 0.18 mmol/L, 95% CI: -0.28, -0.08, I = 6%, p = 0.0004), LDL-C (WMD: -0.21 mmol/L, 95% CI: -0.36, -0.06, I = 75%, p = 0.006), triglycerides (WMD: -0.09 mmol/L, 95% CI: -0.15, -0.04, I = 22%, p = 0.001), and non-HDL-C (WMD: -0.28 mmol/L, 95% CI: -0.45, -0.12, I = 0%, p = 0.0009), and increased HDL-C concentrations (WMD: 0.03 mmol/L, 95% CI: 0.00, 0.06, I = 0%, p = 0.03).

CONCLUSION

Our results suggest that hydroxychloroquine improves lipid parameters by reducing total cholesterol, LDL-C, triglycerides, non-HDL-C, and increasing HDL-C levels.

摘要

背景

有研究表明羟氯喹可能对 LDL-C、HDL-C 和甘油三酯水平有积极影响，但该药的降血脂活性仍不确定。

目的

本荟萃分析旨在探讨羟氯喹对循环脂质浓度的影响。

方法

在 PubMed、Web of Science、Scopus 和 Google Scholar 数据库中检索评估羟氯喹对血脂参数影响的随机对照试验。采用随机效应模型进行荟萃分析，并通过逐一剔除法进行敏感性分析。

结果

荟萃分析显示，接受羟氯喹治疗的患者总胆固醇（WMD：0.18mmol/L，95%CI：-0.28，-0.08，I = 6%，p = 0.0004）、LDL-C（WMD：-0.21mmol/L，95%CI：-0.36，-0.06，I = 75%，p = 0.006）、甘油三酯（WMD：-0.09mmol/L，95%CI：-0.15，-0.04，I = 22%，p = 0.001）和非 HDL-C（WMD：-0.28mmol/L，95%CI：-0.45，-0.12，I = 0%，p = 0.0009）浓度降低，HDL-C 浓度升高（WMD：0.03mmol/L，95%CI：0.00，0.06，I = 0%，p = 0.03）。