Simental-Mendía Luis E, Simental-Mendía Mario, Sahebkar Amirhossein, Rodríguez-Morán Martha, Guerrero-Romero Fernando
Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico.
Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, NL, Mexico.
Eur J Clin Pharmacol. 2017 May;73(5):525-536. doi: 10.1007/s00228-017-2212-8. Epub 2017 Feb 9.
We performed a meta-analysis of randomized controlled trials (RCTs) in order to evaluate the effect of oral magnesium supplementation on lipid profile of both diabetic and non-diabetic individuals.
PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (from inception to February 23, 2016) to identify RCTs evaluating the effect of magnesium on lipid concentrations. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations.
Magnesium treatment was not found to significantly affect plasma concentrations of any of the lipid indices including total cholesterol (WMD 0.03 mmol/L, 95% CI -0.11, 0.16, p = 0.671), LDL-C (WMD -0.01 mmol/L, 95% CI -0.13, 0.11, p = 0.903), HDL-C (WMD 0.03 mmol/L, 95% CI -0.003, 0.06, p = 0.076), and triglycerides concentrations (WMD -0.10 mmol/L, 95% CI -0.25, 0.04, p = 0.149). In a subgroup analysis comparing studies with and without diabetes, no difference was observed between subgroups in terms of changes in plasma total cholesterol (p = 0.924), LDL-C (p = 0.161), HDL-C (p = 0.822), and triglyceride (p = 0.162) concentrations.
Results of the present meta-analysis indicated that magnesium supplementation showed no significant effects on the lipid profile of either diabetic or non-diabetic individuals.
我们进行了一项随机对照试验（RCT）的荟萃分析，以评估口服补充镁对糖尿病和非糖尿病个体血脂谱的影响。
检索了PubMed-Medline、SCOPUS、科学网和谷歌学术数据库（从数据库建立至2016年2月23日），以确定评估镁对血脂浓度影响的随机对照试验。采用随机效应模型和通用逆方差法进行定量数据合成。使用逐一剔除法进行敏感性分析。进行加权随机效应荟萃回归以评估潜在混杂因素对血脂浓度的影响。
未发现镁治疗对任何血脂指标的血浆浓度有显著影响，包括总胆固醇（加权均数差[WMD]0.03 mmol/L，95%置信区间[CI]-0.11，0.16，p = 0.671）、低密度脂蛋白胆固醇（LDL-C）（WMD -0.01 mmol/L，95% CI -0.13，0.11，p = 0.903）、高密度脂蛋白胆固醇（HDL-C）（WMD 0.03 mmol/L，95% CI -0.003，0.06，p = 0.076）和甘油三酯浓度（WMD -0.10 mmol/L，95% CI -0.25，0.04，p = 0.149）。在一项比较有糖尿病和无糖尿病研究的亚组分析中，亚组间在血浆总胆固醇（p = 0.924）、LDL-C（p = 0.161）、HDL-C（p = 0.822）和甘油三酯（p = 0.162）浓度变化方面未观察到差异。
本荟萃分析结果表明，补充镁对糖尿病或非糖尿病个体的血脂谱均无显著影响。
