Ersen Dudu Tuba, Alpaslan Duygu, Aktas Nahit
Department of Mining Engineering, Engineering Faculty, Van Yüzüncü Yıl University, Campus, Van, 65080 Turkey.
Department of Chemical Engineering, Institute of Natural and Applied Science, Van Yüzüncü Yıl University, Campus, Van, 65080 Turkey.
J Polym Environ. 2022;30(2):483-493. doi: 10.1007/s10924-021-02212-4. Epub 2021 Jun 22.
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.
在本研究中，旨在研究含有pH敏感型琼脂（A）、甘油（G）、甜杏仁油（Wu等人，《分子结构杂志》882:107 - 115，2008）的有机水凝胶的合成、表征及药物释放行为。通过使用戊二醛或亚甲基双丙烯酰胺交联剂的乳液技术，经自由基聚合反应合成了含有琼脂、甘油和不同量甜杏仁油的有机水凝胶。然后，对合成的有机水凝胶的溶胀度、键结构、血液相容性和抗氧化性能进行了检测。此外，采用相同的聚合反应合成了负载头孢曲松和奥沙利铂的有机水凝胶，并研究了其释放动力学。在37℃下，于与胃液（pH 2.0）、皮肤表面（pH 5.5）、血液（pH 7.4）和肠液（pH 8.0）pH值相似的介质中进行体外释放研究。研究了交联剂类型和甜杏仁油含量对释放的影响。利用释放结果确定动力学参数，并将这些结果应用于零级和一级方程以及Korsmeyer - Peppas和Higuchi方程。计算了有机水凝胶药物扩散的扩散指数，发现其值与释放结果一致。
