Mattila S, Rauste J, Merikallio E, Mattila T, Tarkka P, Tala P
Ann Chir Gynaecol. 1977;66(6):311-5.
The effects of digoxin on the contractility of orthotopically transplanted heart was studied in dogs. Intravenously administered digoxin produced a fall in the rate and output of the transplanted heart without any change in stroke volume, whereas the output of the intact heart was slightly improved due to a small increase of stroke volume. This difference was thought to be due to the action of digitalis which is mediated via the nervous pathways, which are interrupted in the transplanted heart.
研究了地高辛对犬原位移植心脏收缩性的影响。静脉注射地高辛可使移植心脏的心率和输出量下降，而每搏量无变化；而完整心脏的输出量则因每搏量略有增加而稍有改善。这种差异被认为是由于洋地黄的作用是通过神经途径介导的，而在移植心脏中这些神经途径被中断。
