Mattila S, Rauste J, Merikallio E, Keskitalo E, Tuominen M, Tarkka P, Tala P
Scand J Thorac Cardiovasc Surg. 1975;9(3):175-80. doi: 10.3109/14017437509138635.
The effects of isoprenaline and adrenalin on the myocardial contractility of transplanted heart were studied in 6 mongrel dogs which had undergone orthotopic cardiac transplantation. Isoprenaline and adrenaline produced a fall in end-diastolic and end-systolic volumes, and an increase in stroke volume, cardiac output and velocity of contraction when the heart rate was increased. Similar changes were observed in 4 mongrel dogs tested as controls, with the exception of a less pronounced increase of cardiac output after administration of isoprenaline and adrenalin and a fall in stroke volume associated with a higher acceleration of heart rate after administration of isoprenaline. These minor differences between the transplanted and intact heart were thought to be a reflexion of the increased blood volume following heart transplantation.
在6只接受原位心脏移植的杂种犬中，研究了异丙肾上腺素和肾上腺素对移植心脏心肌收缩力的影响。当心率增加时，异丙肾上腺素和肾上腺素使舒张末期和收缩末期容积降低，每搏量、心输出量和收缩速度增加。在作为对照的4只杂种犬中观察到了类似的变化，但异丙肾上腺素和肾上腺素给药后心输出量增加不太明显，且异丙肾上腺素给药后每搏量降低并伴有心率更快的加速。移植心脏和完整心脏之间的这些细微差异被认为是心脏移植后血容量增加的反映。
