Azrielant Shir, Ellenbogen Eran, Peled Alon, Zemser-Werner Valentina, Samuelov Liat, Sprecher Eli, Pavlovsky Mor
Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Case Rep Dermatol. 2021 Jun 8;13(2):263-270. doi: 10.1159/000515732. eCollection 2021 May-Aug.
Lupus erythematosus (LE) is an autoimmune disorder commonly affecting the skin; cutaneous lesions may indicate systemic involvement, warranting further evaluation. Photosensitivity, which may result in hyperpigmentation, is a well-known feature of the disease. In contrast, the prevalence of primary hyperpigmentation as a presenting sign of LE is not well established. Here, we compare 3 unique cases of diffuse facial hyperpigmentation as the primary manifestation of LE (cutaneous or systemic) and review previously reported cases. Our data highlight the need for considering LE in the differential diagnosis of facial hyperpigmentation and substantiate the importance of this unique lupus variant in early diagnosis and patient evaluation.
红斑狼疮（LE）是一种常见的自身免疫性疾病，通常会影响皮肤；皮肤病变可能表明有全身受累，需要进一步评估。光敏性可能导致色素沉着，是该疾病的一个众所周知的特征。相比之下，原发性色素沉着作为LE的首发症状的患病率尚未明确。在此，我们比较了3例以面部弥漫性色素沉着为LE（皮肤型或系统性）主要表现的独特病例，并回顾了先前报道的病例。我们的数据强调了在面部色素沉着的鉴别诊断中考虑LE的必要性，并证实了这种独特的狼疮变体在早期诊断和患者评估中的重要性。
