Boyd A S
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.
Lupus. 2006;15(5):292-5. doi: 10.1191/0961203306lu2304xx.
Isolated, hyperpigmented lesions arising on the skin of the head and neck in the elderly rarely prompt consideration of connective tissue diseases. Histologic evaluation, however, may reveal changes compatible with chronic cutaneous lupus erythematosus (CCLE). A retrospective review of cutaneous biopsies compatible with CCLE evaluated by the Vanderbilt University Division of Dermatopathology over a five-year period (1998-2002) was undertaken. Cases with isolated lesions arising on the head and neck in patients 40 years or older were selected and the histopathology was confirmed. Patients were interviewed by phone and their charts were reviewed. A total of 11 cases were found, including nine women and two men. These patients averaged 68 years of age and presented with single, hyperpigmented macular lesions. Photosensitivity was rare and no associated stigmata of lupus erythematosus were noted. Response to topical application of corticosteroid preparations was excellent.
老年人头颈部皮肤上出现的孤立性色素沉着病变很少会让人想到结缔组织病。然而，组织学评估可能会发现与慢性皮肤红斑狼疮（CCLE）相符的变化。对范德比尔特大学皮肤病理学部门在五年期间（1998 - 2002年）评估的符合CCLE的皮肤活检进行了回顾性研究。选择了40岁及以上患者头颈部出现孤立性病变的病例，并确认了组织病理学结果。通过电话对患者进行了访谈，并查阅了他们的病历。共发现11例，其中包括9名女性和2名男性。这些患者平均年龄为68岁，表现为单个色素沉着斑疹病变。光敏现象罕见，未发现红斑狼疮相关的体征。局部应用皮质类固醇制剂的反应良好。
