Simoes Jorge Piano, Daoud Elza, Shabbir Maryam, Amanat Sana, Assouly Kelly, Biswas Roshni, Casolani Chiara, Dode Albi, Enzler Falco, Jacquemin Laure, Joergensen Mie, Kok Tori, Liyanage Nuwan, Lourenco Matheus, Makani Punitkumar, Mehdi Muntazir, Ramadhani Anissa L, Riha Constanze, Santacruz Jose Lopez, Schiller Axel, Schoisswohl Stefan, Trpchevska Natalia, Genitsaridi Eleni
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
Front Aging Neurosci. 2021 Jun 11;13:647285. doi: 10.3389/fnagi.2021.647285. eCollection 2021.
Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.
耳鸣在个人和社会层面都是一种负担沉重的病症。该病症的许多方面仍不明确,包括其潜在机制,这最终阻碍了治愈方法的开发。需要采用跨学科方法来克服长期存在的研究挑战。本综述总结了耳鸣相关各个研究领域的当前知识,包括耳鸣产生机制、异质性、流行病学、评估和治疗开发,旨在突出主要挑战并为未来研究克服这些挑战提供建议。不同领域的四个共同主题被确定为未来研究方向:(1)进一步建立多中心和多学科合作;(2)对现有知识进行系统评价和综合;(3)研究方法的标准化,包括耳鸣评估、数据采集和数据分析方案;(4)设计大样本量研究并创建大型耳鸣特异性数据库,以便深入探索耳鸣异质性。