Kunieda Yota, Arakawa Chiaki, Yamada Takumi, Suzuki Mizue, Koyama Shingo, Kimura Yosuke, Ichikawa Takeo, Shino Shuhei, Yamada Minoru, Hirokawa Ryuto, Matsuda Tadamitsu, Takakura Tomokazu, Adachi Tomohide, Hoshino Haruhiko
Department of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Dement Geriatr Cogn Dis Extra. 2021 May 6;11(2):91-98. doi: 10.1159/000515864. eCollection 2021 May-Aug.
The regional cerebral blood flow (rCBF) distribution can affect brain functioning, leading to amnestic mild cognitive impairment (aMCI) and mild Alzheimer disease (AD). This study aimed to clarify the detailed characteristics of rCBF distribution in patients with mild AD and aMCI.
This cross-sectional study from April 2015 to March 2018 included 103 older adults (mean age 78.9 years; 60% females), out of a total of 302 adults, and categorized them into 3 groups according to cognitive symptoms. The normal control (NC), aMCI, and mild AD groups included 20, 50, and 33 participants, respectively. The primary outcome was rCBF, which was compared among the 3 groups using a 2-sample test without correction for multiple comparisons.
In the aMCI group, the rCBF decreased in the bilateral parietal and left frontal association cortex and the bilateral premotor cortex ( < 0.01) but increased in the bilateral cerebellum ( < 0.01). In the mild AD group, the rCBF decreased in the bilateral parietal and occipital association cortex, the bilateral premotor cortex, the left temporal and frontal association cortex, and the left limbic lobe ( < 0.01). Conversely, the rCBF increased in some parts of the cerebellum, the bilateral frontal and temporal association cortex, the left occipital association cortex, and the right premotor cortex ( < 0.01).
Based on the analysis of the values obtained, it was inferred that the rCBF undergoes reduction and elevation in aMCI and AD patients.
局部脑血流量（rCBF）分布会影响脑功能，导致遗忘型轻度认知障碍（aMCI）和轻度阿尔茨海默病（AD）。本研究旨在阐明轻度AD和aMCI患者rCBF分布的详细特征。
这项2015年4月至2018年3月的横断面研究纳入了302名成年人中的103名老年人（平均年龄78.9岁；60%为女性），并根据认知症状将他们分为3组。正常对照组（NC）、aMCI组和轻度AD组分别包括20名、50名和33名参与者。主要结局指标是rCBF，使用两样本检验在3组之间进行比较，未对多重比较进行校正。
在aMCI组中，双侧顶叶和左侧额叶联合皮质以及双侧运动前皮质的rCBF降低（<0.01），但双侧小脑的rCBF升高（<0.01）。在轻度AD组中，双侧顶叶和枕叶联合皮质、双侧运动前皮质、左侧颞叶和额叶联合皮质以及左侧边缘叶的rCBF降低（<0.01）。相反，小脑的某些部位、双侧额叶和颞叶联合皮质、左侧枕叶联合皮质以及右侧运动前皮质的rCBF升高（<0.01）。
基于对所得值的分析，推断aMCI和AD患者的rCBF会降低和升高。
