Department of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Curr Alzheimer Res. 2022;19(6):458-468. doi: 10.2174/1567205019666220627091246.
No previous study has examined the effect of dual-task training using changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) as an outcome.
This study aimed to examine the effects of simultaneous dual-task training of exercise and cognitive tasks on rCBF using SPECT in older adults with amnestic mild cognitive impairment (aMCI).
In this non-randomized control trial, 40 older adults with aMCI participated from May 2016 to April 2018. Outpatients in the intervention group (n = 22) underwent 24 sessions (12 months) of dualtask training twice a month for 60 mins per session. Participants in the control group (n = 18) continued to have regular outpatient visits. The primary outcome was rCBF at baseline and after 12 months, which was compared in each group using the two-sample t-test. The secondary outcomes were the rate of reversion and conversion from aMCI after 12 months.
Of the 22 participants in the intervention group, six dropped out; therefore, 16 were included in the analysis. The intervention group showed more significant increases in rCBF in multiple regions, including the bilateral frontal lobes, compared with the control group. However, the rates of reversion or conversion from mild cognitive impairment (MCI) were not significantly different.
Dual-task training for older adults with aMCI increased rCBF in the frontal gyrus but did not promote reversion from MCI to normal cognition. Future intervention studies, such as follow-up examinations after the intervention, are warranted to consider long-term prognosis.
以前没有研究使用单光子发射计算机断层扫描 (SPECT) 作为结果来检查使用区域脑血流 (rCBF) 变化的双重任务训练的效果。
本研究旨在检查在有遗忘型轻度认知障碍 (aMCI) 的老年人中，同时进行运动和认知任务的双重任务训练对 SPECT 中 rCBF 的影响。
在这项非随机对照试验中，共有 40 名患有 aMCI 的老年人参加，时间从 2016 年 5 月到 2018 年 4 月。干预组的门诊患者（n=22）接受了 24 次（12 个月）双重任务训练，每月两次，每次 60 分钟。对照组（n=18）的患者继续进行常规门诊就诊。主要结局是基线和 12 个月后的 rCBF，采用两样本 t 检验比较两组之间的 rCBF。次要结局是 12 个月后从 aMCI 恢复或转变的比率。
干预组的 22 名参与者中有 6 人退出，因此有 16 人被纳入分析。与对照组相比，干预组 rCBF 在多个区域（包括双侧额叶）的增加更为显著。然而，从轻度认知障碍 (MCI) 恢复或转变的比率没有显著差异。
对有 aMCI 的老年人进行双重任务训练可增加额回的 rCBF，但不能促进从 MCI 恢复为正常认知。需要进一步的干预研究，例如干预后的随访检查，以考虑长期预后。
