Komatsu M, Kondo T, Yamauchi K, Yokokawa N, Ichikawa K, Ishihara M, Aizawa T, Yamada T, Imai Y, Tanaka K
Department of Gerontology, Shinshu University School of Medicine, Nagano-ken, Japan.
J Clin Endocrinol Metab. 1988 Oct;67(4):633-8. doi: 10.1210/jcem-67-4-633.
The frequency of detection of serum antibodies against pituitary cells was determined in 32 patients with the primary empty sella syndrome. Antibodies reacting with corticotropin-secreting mouse AtT20 and PRL-secreting rat GH3 cells were found in 24 (75%) and 15 (47%), respectively, of the 32 patients; 14 patients (44%) had antibodies reacting with both cell lines. In patients with pituitary adenomas, the prevalence of antipituitary antibodies was significantly lower than in those with the empty sella syndrome; 1 of 9 acromegalic patients had antibodies reacting with GH3 cells, and 2 of 9 prolactinoma patients and 1 of 7 patients with nonfunctioning adenomas had antibodies reacting with both AtT20 and GH3 cells. Among 6 patients with idiopathic diabetes insipidus, 1 patient had antibodies reacting with AtT20 and GH3 cells, and 2 patients had antibodies reacting with either AtT20 or GH3 cells. None of 5 patients with established autoimmune diseases (3 with systemic lupus erythematosus and 2 with autoimmune adrenal failure) had antipituitary antibodies in their serum. These results suggest that pituitary antibodies may be related to the development of pituitary atrophy and the primary empty sella syndrome, and that the test may be clinically useful as a screening test for the empty sella syndrome.
在32例原发性空蝶鞍综合征患者中测定了血清抗垂体细胞抗体的检出频率。在这32例患者中，分别有24例（75%）和15例（47%）发现与分泌促肾上腺皮质激素的小鼠AtT20细胞及分泌催乳素的大鼠GH3细胞发生反应的抗体；14例患者（44%）具有与两种细胞系均发生反应的抗体。在垂体腺瘤患者中，抗垂体抗体的患病率显著低于空蝶鞍综合征患者；9例肢端肥大症患者中有1例具有与GH3细胞发生反应的抗体，9例催乳素瘤患者中有2例以及7例无功能腺瘤患者中有1例具有与AtT20和GH3细胞均发生反应的抗体。在6例特发性尿崩症患者中，1例具有与AtT20和GH3细胞发生反应的抗体，2例具有与AtT20或GH3细胞发生反应的抗体。5例确诊为自身免疫性疾病的患者（3例系统性红斑狼疮和2例自身免疫性肾上腺功能衰竭）血清中均无抗垂体抗体。这些结果提示，垂体抗体可能与垂体萎缩及原发性空蝶鞍综合征的发生有关，并且该检测作为空蝶鞍综合征的筛查试验可能具有临床应用价值。
