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Weight gain following treatment of hyperthyroidism-A forgotten tale.甲状腺功能亢进症治疗后的体重增加——一个被遗忘的故事。
Clin Obes. 2019 Oct;9(5):e12328. doi: 10.1111/cob.12328. Epub 2019 Jul 3.
2
Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease.格雷夫斯病从甲状腺功能亢进转变为甲状腺功能正常期间的生理和代谢变化
Thyroid. 2016 Oct;26(10):1422-1430. doi: 10.1089/thy.2015.0602. Epub 2016 Sep 7.
3
Hyperthyroidism.甲状腺功能亢进症
Lancet. 2016 Aug 27;388(10047):906-918. doi: 10.1016/S0140-6736(16)00278-6. Epub 2016 Mar 30.
4
Thyroid hormone as a determinant of metabolic and contractile phenotype of skeletal muscle.甲状腺激素作为骨骼肌代谢和收缩表型的决定因素。
Thyroid. 2008 Feb;18(2):205-16. doi: 10.1089/thy.2007.0256.
5
Neuromuscular complications of thyrotoxicosis.甲状腺毒症的神经肌肉并发症
Clin Endocrinol (Oxf). 2007 Nov;67(5):645-50. doi: 10.1111/j.1365-2265.2007.02909.x. Epub 2007 Jun 11.
6
Work capacity and oxygen uptake abnormalities in hyperthyroidism.甲状腺功能亢进症中的工作能力和摄氧量异常。
Minerva Cardioangiol. 2006 Jun;54(3):355-62.
7
The impact of overt and subclinical hyperthyroidism on skeletal muscle.显性和亚临床甲状腺功能亢进对骨骼肌的影响。
Thyroid. 2006 Apr;16(4):375-80. doi: 10.1089/thy.2006.16.375.
8
A Biometric Study of Human Basal Metabolism.人体基础代谢的生物特征研究。
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9
Subnormal energy expenditure: a putative causal factor in the weight gain induced by treatment of hyperthyroidism.能量消耗低于正常水平：甲状腺功能亢进症治疗引起体重增加的一个假定因果因素。
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Ann Intern Med. 2003 Aug 5;139(3):205-13.

甲状腺功能亢进症患者的体重变化：一项为期一年的重复测量研究中的时间规律及可能解释

Body Weight Changes in Hyperthyroidism: Timing and Possible Explanations during a One Year Repeated Measurement Study.

作者信息

Karmisholt Jesper, Carlé Allan, Andersen Stig

机构信息

Department of Medical Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Clinical Institute, Aalborg University, Aalborg, Denmark.

出版信息

Eur Thyroid J. 2021 Jun;10(3):208-214. doi: 10.1159/000512078. Epub 2020 Dec 2.

DOI:10.1159/000512078
PMID:34178706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8215962/
Abstract

BACKGROUND

Weight gain during treatment of hyperthyroidism is a frequent and for many patients unwanted outcome. With this repeated measurement study, we explored the timing of weight changes during the first year of antithyroid drug (ATD) treatment and assessed the correlation between body weight changes and changes in thyroid hormones, resting energy expenditure (REE), physical activity level, and energy efficiency.

METHODS

Patients with new onset hyperthyroidism were investigated every second month during the first year of ATD treatment. At each investigation, the following were measured: body weight, thyroid hormone concentrations, physical activity level, and daily number of steps, REE, and exercise performance.

RESULTS

Two men and eleven women, all sedentary, mean age 49(SD: 9.3) years were included. Significant changes after 1 year occurred for body weight (68.9-74.1 kg), thyroid hormones (free T3 [fT3] 17.5 to 4.42 pmol/L), REE (1,630-1,484 kcal/24 h), and energy efficiency at lower (50 W) workloads (16.0-17.6%). In individual patients, only REE and fT3 correlated to changes in body weight. Physical activity level did not change during treatment.

CONCLUSION

In this study, treatment of hyperthyroidism was associated with marked increase in body weight in the patients. This increase correlated to a decrease in REE and only to a negligible extent to changes in energy efficiency and not at all to changes in physical activity level of daily living.

摘要

背景

甲状腺功能亢进症治疗期间体重增加是常见现象，且许多患者对此并不期望。通过这项重复测量研究，我们探究了抗甲状腺药物（ATD）治疗第一年体重变化的时间，并评估了体重变化与甲状腺激素、静息能量消耗（REE）、身体活动水平和能量效率变化之间的相关性。

方法

新诊断为甲状腺功能亢进症的患者在接受ATD治疗的第一年每两个月接受一次调查。每次调查时，测量以下指标：体重、甲状腺激素浓度、身体活动水平、每日步数、REE和运动表现。

结果

纳入了2名男性和11名女性，均为久坐不动者，平均年龄49（标准差：9.3）岁。1年后，体重（68.9 - 74.1千克）、甲状腺激素（游离T3 [fT3]从17.5降至4.42皮摩尔/升）、REE（从1630千卡/24小时降至1484千卡/24小时）以及较低（50瓦）工作负荷下的能量效率（从16.0%升至17.6%）均发生了显著变化。在个体患者中，只有REE和fT3与体重变化相关。治疗期间身体活动水平未发生变化。

结论

在本研究中，甲状腺功能亢进症的治疗与患者体重显著增加有关。这种增加与REE降低相关，与能量效率变化的相关性可忽略不计，与日常生活身体活动水平变化则完全无关。