Kung Annie W C
Department of Medicine, The University of Hong Kong, Hong Kong, China.
Clin Endocrinol (Oxf). 2007 Nov;67(5):645-50. doi: 10.1111/j.1365-2265.2007.02909.x. Epub 2007 Jun 11.
Thyroid hormones exert multiple effects on the neuromuscular system and the brain, with the most important being their role in stimulating the development and differentiation of the neuromuscular system and brain in foetal and neonatal life. In the presence of hyperthyroidism, muscular and neurological symptoms may be the presenting clinical features of the disease. The frequency and severity of neuromuscular complications vary considerably and are probably related to the degree of hyperthyroidism, although in some patients the neuromuscular dysfunction is caused by associated disorders rather than by hyperthyroidism per se. This update focuses on the most common neurological and muscular disorders that occur in patients with thyrotoxicosis. It is beyond the scope of this paper to discuss thyroid eye disease and cardiac complications, in themselves separate complications of specific myocytes.
甲状腺激素对神经肌肉系统和大脑具有多种作用，其中最重要的是它们在胎儿和新生儿期刺激神经肌肉系统和大脑发育及分化方面所起的作用。在甲状腺功能亢进的情况下，肌肉和神经症状可能是该疾病的主要临床特征。神经肌肉并发症的发生率和严重程度差异很大，可能与甲状腺功能亢进的程度有关，尽管在一些患者中，神经肌肉功能障碍是由相关疾病引起的，而非甲状腺功能亢进本身。本综述聚焦于甲状腺毒症患者中最常见的神经和肌肉疾病。本文不讨论甲状腺眼病和心脏并发症，它们本身是特定心肌细胞的单独并发症。
