Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), MEPHI, Marseille, France.
Microbes, Evolution, Phylogénie et Infection (MEPHI), IHU - Méditerranée Infection, Marseille, France.
Front Cell Infect Microbiol. 2021 Jun 11;11:639177. doi: 10.3389/fcimb.2021.639177. eCollection 2021.
Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood pressure by acting on the angiotensin II type 1 receptor (AT1R). ARBs have been reported to trigger the modulation of the angiotensin I converting enzyme 2 (ACE2), the receptor used by the virus to penetrate susceptible cells, raising concern that such treatments may promote virus capture and increase their viral load in patients receiving ARBs therapy. In this study, we reviewed the effect of ARBs on ACE2 and AT1R expression and investigated whether treatment of permissive ACE2+/AT1R+ Vero E6 cells with ARBs alters SARS-CoV-2 replication in an angiotensin II-free system. After treating the cells with the ARBs, we observed an approximate 50% relative increase in SARS-CoV-2 production in infected Vero E6 cells that correlates with the ARBs-induced up-regulation of ACE2 expression. From this data, we believe that the use of ARBs in hypertensive patients infected by SARS-CoV-2 should be carefully evaluated.
几种合并症，包括高血压，与 SARS-CoV-2 感染期间发生严重疾病的风险增加有关。血管紧张素 II 受体阻滞剂（ARB）通过作用于血管紧张素 II 型 1 受体（AT1R），是目前用于控制血压的最广泛使用的药物之一。据报道，ARB 可触发血管紧张素 I 转换酶 2（ACE2）的调节，病毒利用 ACE2 进入易感细胞，这引起了人们的担忧，即此类治疗可能会促进病毒捕获，并增加接受 ARB 治疗的患者的病毒载量。在这项研究中，我们综述了 ARB 对 ACE2 和 AT1R 表达的影响，并研究了在没有血管紧张素 II 的系统中，ARB 治疗是否会改变允许 ACE2+/AT1R+Vero E6 细胞中的 SARS-CoV-2 复制。在用 ARB 处理细胞后，我们观察到感染的 Vero E6 细胞中 SARS-CoV-2 的产量相对增加了约 50%，这与 ARB 诱导的 ACE2 表达上调相关。根据这些数据，我们认为，在感染 SARS-CoV-2 的高血压患者中使用 ARB 应谨慎评估。
Zotero 插件
