Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland.
Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-265 Bialystok, Poland.
Cells. 2022 Apr 26;11(9):1458. doi: 10.3390/cells11091458.
The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.
流行病学观察表明，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的呼吸道和胃肠道症状伴有短期和长期的神经系统表现。越来越多的证据表明，SARS-CoV-2 的神经侵袭潜力与其与细胞膜唾液酸组相互作用的能力密切相关。鉴于细胞膜上唾液酸化化合物在大脑中的广泛表达，细胞膜唾液糖蛋白与病毒之间的相互作用对于其附着和细胞进入、运输、神经元损伤和大脑免疫至关重要。在这里，我们重点关注大脑唾液酸组在 2019 年冠状病毒病（COVID-19）和 SARS-CoV-2 诱导的神经病理学进展中的意义。
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