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CRISPR基因编辑技术先驱荣获2020年诺贝尔化学奖。

CRISPR Pioneers Win 2020 Nobel Prize for Chemistry.

作者信息

Farhud Dariush D, Zarif-Yeganeh Marjan

机构信息

School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Department of Basic Sciences/Ethics, Academy of Medical Sciences, Tehran, Iran.

出版信息

Iran J Public Health. 2020 Dec;49(12):2235-2239. doi: 10.18502/ijph.v49i12.4800.

Abstract

Over the last few years, the development of genome editing has revolutionized research on the human genome. Recent advances in developing programmable nucleases, such as meganucleases, ZFNs, TALENs and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas, has greatly expedited the progress of gene editing from concept to clinical practice. The CRISPR has advantages over other nuclease-based genome editing tools due to its high accuracy, efficiency, and strong specificity. Eight years after CRISPR application for human genome edition by Emmanuelle Charpentier and Jennifer A. Doudna, the 2020 Nobel Prize in Chemistry has been jointly given to them for development of CRISPR-Cas9 gene editing, allows scientists to precisely cut and edit of DNA.

摘要

在过去几年中,基因组编辑的发展彻底改变了人类基因组研究。在开发可编程核酸酶方面的最新进展,如巨核酸酶、锌指核酸酶(ZFN)、转录激活样效应因子核酸酶(TALEN)和规律成簇间隔短回文重复序列(CRISPR)/Cas,极大地加快了基因编辑从概念到临床实践的进程。CRISPR因其高精度、高效率和强特异性,相较于其他基于核酸酶的基因组编辑工具具有优势。在艾曼纽·夏彭蒂耶(Emmanuelle Charpentier)和詹妮弗·A·杜德纳(Jennifer A. Doudna)将CRISPR应用于人类基因组编辑八年后,2020年诺贝尔化学奖联合授予她们,以表彰她们开发了CRISPR-Cas9基因编辑技术,该技术使科学家能够精确切割和编辑DNA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/746f/8215069/4cc58689c14c/IJPH-49-2235-g001.jpg

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