Gulistan Bahat, Istanbul University, Istanbul Medical School, Department of Internal Medicine, Capa, 34390, Istanbul, Turkey, Telephone: + 90 212 414 20 00-33204, Fax: + 90 212 532 42 08, E-mail address:
J Nutr Health Aging. 2021;25(6):757-761. doi: 10.1007/s12603-021-1617-3.
BACKGROUND/OBJECTIVE: In 2018 EWGSOP2 has suggested low muscle strength as the primary parameter of sarcopenia. The consensus has recommended SARC-F questionnaire as a screening test to find cases with low muscle strength which has been designated as probable sarcopenia. We aimed to study the ability of SARC-F to find probable sarcopenia cases in older patients.
Retrospective, cross-sectional.
Istanbul University Istanbul Faculty of Medicine.
A total of 456 older adults (71.1% female, mean age: 74.6±6.6 years).
We diagnosed probable sarcopenia by EWGSOP 2 criteria, i.e., presence of low handgrip strength (HGS). SARC-F questionnaire was performed by all participants. We used a receiver operating characteristics curve to obtain SARC-F cut-off values to detect probable sarcopenia and calculated the area under the curve and 95% confidence interval (CI).
We included 456 participants (71.1% female; mean age: 74.6 ± 6.6 years). Probable sarcopenia was present in 58 (12.7%). SARC-F cut-off ≥ 2 presented the best balance between sensitivity and specificity (sensitivity: 64.9% vs specificity: 67.9%) to detect probable sarcopenia [the area under the receiver operating characteristics curve (AUC) = 0.710; 95% Cl: 0.660-0.752, p< 0.001]. SARC-F with a cut-off point ≥ 1 had sensitivity 84.2% and specificity 40.5% and SARC-F ≥ 4 had high specificity 88.2% with 40.3% sensitivity.
SARC-F is a good screening tool for sarcopenia in practice. Our findings suggest SARC-F ≥ 1 cut-off point to be used as the probable sarcopenia screening tool regarding its high sensitivity. Consequently, SARC-F ≥ 4 cut-off is better to be used if one prefers to exclude probable sarcopenia.
背景/目的：2018 年 EWGSOP2 建议低肌肉力量作为肌少症的主要参数。共识建议 SARC-F 问卷作为一种筛选试验来发现低肌肉力量的病例，这被指定为可能的肌少症。我们旨在研究 SARC-F 在老年患者中发现可能的肌少症病例的能力。
回顾性、横断面研究。
伊斯坦布尔大学伊斯坦布尔医学院。
共 456 名老年人（71.1%为女性，平均年龄：74.6±6.6 岁）。
我们根据 EWGSOP 2 标准诊断为可能的肌少症，即存在低握力（HGS）。所有参与者均进行 SARC-F 问卷调查。我们使用受试者工作特征曲线获得 SARC-F 截断值以检测可能的肌少症，并计算曲线下面积和 95%置信区间（CI）。
我们纳入了 456 名参与者（71.1%为女性；平均年龄：74.6 ± 6.6 岁）。58 名（12.7%）存在可能的肌少症。SARC-F 截断值≥2 具有最佳的敏感性和特异性之间的平衡（敏感性：64.9%vs特异性：67.9%）来检测可能的肌少症[受试者工作特征曲线下面积（AUC）=0.710；95%Cl：0.660-0.752，p<0.001]。SARC-F 的截断值≥1 的敏感性为 84.2%，特异性为 40.5%，SARC-F≥4 的特异性为 88.2%，敏感性为 40.3%。
SARC-F 是一种用于实践中肌少症的良好筛选工具。我们的研究结果表明，SARC-F≥1 作为可能的肌少症筛选工具具有较高的敏感性。因此，如果希望排除可能的肌少症，则最好使用 SARC-F≥4 截断值。
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