Yang Ming, Hu Xiaoyi, Xie Lingling, Zhang Luoying, Zhou Jie, Lin Jing, Wang Ying, Li Yaqi, Han Zengli, Zhang Daipei, Zuo Yun, Li Ying, Wu Linna
The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University The Health Management Center, Shangjin Nanfu Hospital The Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Medicine (Baltimore). 2018 Jul;97(30):e11726. doi: 10.1097/MD.0000000000011726.
A 3-item SARC-F (termed SARC-F-3 in our study) was recently suggested as a screening tool for sarcopenia.The aim of this study was to compare the diagnostic value of SARC-F-3 to SARC-F in community-dwelling older people.We conducted a diagnostic accuracy study in an urban community in Chengdu, China. People aged 60 years or older were included. Muscle mass, strength, and physical performance were measured by a bio-impedance analysis (BIA) device, handgrip strength, and gait speed test, respectively. The Asia Working Group for Sarcopenia (AWGS) criteria were applied as the "gold reference." The sensitivity/specificity analyses of SARC-F and SARC-F-3 were performed. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were applied to compare the overall accuracy of SARC-F and SARC-F-3. The cut-off points of SARC-F-3 for sarcopenia were determined using the Youden index method.A total of 384 older people aged 71.5 ± 5.8 years were included. On the basis of the AWGS criteria, the prevalence of sarcopenia in our study population was 15.9%. The optimal cut-off point of SARC-F-3 for identifying sarcopenia was a total score of ≥ 2. In the whole study population, the sensitivity and specificity of SARC-F were 29.5% [95% confidence interval (95% CI): 18.5-42.6] and 98.1% (95% CI: 96.0-99.3), respectively, whereas the sensitivity and specificity of SARC-F-3 were 13.1% (95% CI: 5.8-24.2) and 97.8% (95% CI: 95.6-99.1), respectively. The AUCs of SARC-F and SARC-F-3 were 0.894 (95% CI: 0.859-0.923) and 0.676 (95% CI: 0.627-0.723), respectively (P < .001).The 3-item SARC-F may not be suitable for screening sarcopenia in community-dwelling older people.
一种包含3个条目的SARC-F（在我们的研究中称为SARC-F-3）最近被提议作为肌肉减少症的筛查工具。本研究的目的是比较SARC-F-3与SARC-F在社区居住老年人中诊断肌肉减少症的价值。我们在中国成都的一个城市社区进行了一项诊断准确性研究。纳入年龄在60岁及以上的人群。分别通过生物电阻抗分析（BIA）设备、握力和步态速度测试来测量肌肉质量、力量和身体表现。采用亚洲肌肉减少症工作组（AWGS）的标准作为“金标准”。对SARC-F和SARC-F-3进行了敏感性/特异性分析。应用受试者工作特征（ROC）曲线和ROC曲线下面积（AUC）来比较SARC-F和SARC-F-3的总体准确性。使用约登指数法确定SARC-F-3诊断肌肉减少症的切点。共纳入384名年龄为71.5±5.8岁的老年人。根据AWGS标准，我们研究人群中肌肉减少症的患病率为15.9%。识别肌肉减少症的SARC-F-3的最佳切点是总分≥2。在整个研究人群中，SARC-F的敏感性和特异性分别为29.5%[95%置信区间（95%CI）：18.5 - 42.6]和98.1%（95%CI：96.0 - 99.3），而SARC-F-3的敏感性和特异性分别为13.1%（95%CI：5.8 - 24.2）和97.8%（95%CI：95.6 - 99.1）。SARC-F和SARC-F-3的AUC分别为0.894（95%CI：0.859 - 0.923）和0.676（95%CI：0.627 - 0.723）（P < 0.001）。包含3个条目的SARC-F可能不适用于筛查社区居住老年人中的肌肉减少症。
