Department of Pathology, Perdana University, Selangor, Malaysia.
Clinipath Pathology (M) Sdn Bhd, Klang, Malaysia.
West Afr J Med. 2021 Jun 26;38(6):604-606.
Adenocarcinoma constitutes around 0.5 to 2% of all neoplastic lesions of the urinary bladder, out of which, the mucinous variant is seen on rare occasions. Intestinal metaplasia resulting from nephrolithiasis, chronic inflammation and hydronephrosis could be the precursor lesion. Bladder exstrophy and remnants of the urachus are considered as other possible risk factors. The tumour prefers patients who are over 50 years. Hematuria, difficult voiding and suprapubic pain are the most common presenting symptoms. The tumour has a very bad prognosis and is poorly responsive to chemo and radiotherapy and hence surgery is the treatment of choice. Hence early diagnosis is of paramount importance. While managing adenocarcinoma of the bladder, it is important to rule out any possibility of a metastatic lesion that could have come from other organs where mucinous adenocarcinoma is more common.
腺癌约占所有膀胱肿瘤的 0.5%至 2%，其中罕见情况下可见黏液性变异型。肾结石、慢性炎症和肾积水导致的肠上皮化生可能是癌前病变。膀胱外翻和脐尿管残余被认为是其他可能的危险因素。这种肿瘤多见于 50 岁以上的患者。血尿、排尿困难和耻骨上疼痛是最常见的症状。这种肿瘤预后非常差，对化疗和放疗反应不佳，因此手术是首选治疗方法。因此，早期诊断至关重要。在治疗膀胱癌时，必须排除其他可能来自其他更常见黏液性腺癌的器官的转移性病变的可能性。
