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The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke.

作者信息

Prasanth Mani Iyer, Tencomnao Tewin, Brimson James Michael

机构信息

Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

出版信息

Expert Opin Ther Targets. 2021 Jul;25(7):613-614. doi: 10.1080/14728222.2021.1948016. Epub 2021 Jul 8.

DOI:10.1080/14728222.2021.1948016
PMID:34180350
Abstract
摘要

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Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders.针对西格玛受体治疗神经退行性和神经发育障碍。
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Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke.
sigma-1 受体调控的浸润循环巨噬细胞/小胶质细胞的吞噬作用可保护神经元免受损伤，并促进脑缺血性中风后的功能恢复。
Theranostics. 2023 Jan 1;13(2):543-559. doi: 10.7150/thno.77088. eCollection 2023.
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Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy.能够降低 SARS-CoV-2 感染住院率和死亡率的药物：sigma-1 受体和自噬的可能作用。
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