一种来自海洋海绵的新酰胺。

A new amide from the marine sponge .

机构信息

Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, Guangdong, P. R. China.

出版信息

Nat Prod Res. 2023 Jan;37(1):1-7. doi: 10.1080/14786419.2021.1941950. Epub 2021 Jun 28.

DOI:10.1080/14786419.2021.1941950

PMID:34180744

Abstract

A new amide, baeriamide (1), along with nine known diketopiperazines (2-10), was isolated from the marine sponge Haliclona baeri. Their structures were identified by the means of UV, IR, MS and NMR. The absolute configuration of 1 was established by Marfey's method and comparing the specific optical rotation with the known compound HCO-Val-Gly methyl ester. Compound 1 was derived from dehydration of formylated L-valine with γ-amino-butanoic acid methyl ester. Compounds 2-10 were isolated from the genus of Haliclona for the first time. The absolute confirmation of 7 was confirmed first by the means of single-crystal X-ray diffraction. The cytotoxic, antibacterial, antiviral and antifouling activities of these compounds were also tested. However, none of them exhibited significant bioactivities.

摘要

一种新的酰胺，baeriamide（1），以及 9 种已知的二酮哌嗪（2-10），从海洋海绵 Haliclona baeri 中分离出来。通过 UV、IR、MS 和 NMR 等手段确定了它们的结构。1 的绝对构型通过 Marfey 法确定，并通过与已知化合物 HCO-Val-Gly 甲酯的比旋光度进行比较。化合物 1 是由甲酰化 L-缬氨酸与γ-氨基丁酸甲酯脱水得到的。化合物 2-10 是首次从 Haliclona 属中分离得到的。7 的绝对构型首次通过单晶 X 射线衍射确定。还测试了这些化合物的细胞毒性、抗菌、抗病毒和防污活性。然而，它们都没有表现出显著的生物活性。