Jang Kyoung Hwa, Kang Gyoung Won, Jeon Ju-Eun, Lim Chaemin, Lee Hyi-Seung, Sim Chung J, Oh Ki-Bong, Shin Jongheon
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Seoul 151-742, Korea.
Org Lett. 2009 Apr 16;11(8):1713-6. doi: 10.1021/ol900282m.
Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.
卤克隆宁A（1）是一种新型骨架类别的大环二酰胺，从采集于韩国海域的海洋海绵Haliclona sp.中分离得到。该化合物的结构通过光谱分析和化学分析相结合的方法确定。这种新化合物对多种微生物菌株表现出中等程度的细胞毒性和抗菌活性。
