[裂谷热病毒与神奇的NSs蛋白]

[Rift Valley fever virus and the amazing NSs protein].

作者信息

Léger Psylvia, Lozach Pierre-Yves

机构信息

CellNetworks, CIID (Cluster of Excellence and Center for Integrative Infectious Disease Research), Virology, University hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Allemagne.

CellNetworks, CIID (Cluster of Excellence and Center for Integrative Infectious Disease Research), Virology, University hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Allemagne - Univ. Lyon, INRAe, EPHE, IVPC (Infections virales et pathologie comparée), 50 avenue Tony Garnier, 69007 Lyon, France.

出版信息

Med Sci (Paris). 2021 Jun-Jul;37(6-7):601-608. doi: 10.1051/medsci/2021090. Epub 2021 Jun 28.

DOI:10.1051/medsci/2021090

PMID:34180819

Abstract

Rift Valley Fever Virus (RVFV) is an emerging zoonotic pathogen transmitted to humans and livestock through mosquito bites, which was first isolated in Kenya in 1930. The virus is classified by the WHO among the pathogens for which there is an urgent need to develop research, diagnostics, and therapies. However, the efforts developed to control the virus remain limited, and the virus is not well characterized. In this article, we will introduce RVFV and then focus on its virulence factor, the nonstructural protein NSs. We will mainly discuss the ability of this viral protein to form amyloid-like fibrils and its implication in the neurotoxicity associated with RVFV infection.

摘要

裂谷热病毒（RVFV）是一种新出现的人畜共患病原体，通过蚊虫叮咬传播给人类和牲畜，于1930年在肯尼亚首次分离出来。该病毒被世界卫生组织列为迫切需要开展研究、诊断和治疗的病原体之一。然而，为控制该病毒所做的努力仍然有限，而且对该病毒的特性了解不足。在本文中，我们将介绍裂谷热病毒，然后重点关注其毒力因子——非结构蛋白NSs。我们将主要讨论这种病毒蛋白形成淀粉样纤维的能力及其与裂谷热病毒感染相关的神经毒性。