Bouhouche Khaled, Le Borgne Pierrick, Lemullois Michel, Tassin Anne-Marie
Université Paris-Saclay, CEA, CNRS, Institut de biologie intégrative de la cellule (I2BC), 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Med Sci (Paris). 2021 Jun-Jul;37(6-7):632-638. doi: 10.1051/medsci/2021087. Epub 2021 Jun 28.
The cilium is a cell extension forming a distinct compartment of eukaryotic cell body with a complex and dynamic structure. This structure is highly conserved across species and ensures various functions as sensory and motility. In humans, ciliary dysfunction results in diseases (ciliopathies) that can affect all organs. Thanks to its complex ciliary structure, the unicellular and ciliated microorganism, Paramecium, constitutes a model of choice not only to study the structure, assembly and function of cilia but also to validate the specific role of mutations of genes linked to the ciliopathies.
纤毛是一种细胞延伸结构,形成真核细胞体中一个独特的区室,具有复杂且动态的结构。这种结构在物种间高度保守,并确保了诸如感知和运动等多种功能。在人类中,纤毛功能障碍会导致影响所有器官的疾病(纤毛病)。单细胞纤毛微生物草履虫由于其复杂的纤毛结构,不仅构成了研究纤毛结构、组装和功能的理想模型,还可用于验证与纤毛病相关基因的突变的特定作用。