用于光触发控制细菌生物膜和病毒灭活的聚氯乙烯核黄素表面改性

Riboflavin Surface Modification of Poly(vinyl chloride) for Light-Triggered Control of Bacterial Biofilm and Virus Inactivation.

作者信息

Munoz Marcelo, El-Khoury Antony, Eren Cimenci Cagla, Gonzalez-Gomez Mayte, Hunter Robert A, Lomboni David, Variola Fabio, Rotstein Benjamin H, Vono Lucas L R, Rossi Liane M, Edwards Ana Maria, Alarcon Emilio I

机构信息

BEaTS Research, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7, Canada.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

出版信息

ACS Appl Mater Interfaces. 2021 Jul 14;13(27):32251-32262. doi: 10.1021/acsami.1c08042. Epub 2021 Jun 28.

DOI:10.1021/acsami.1c08042

PMID:34181389

Abstract

Poly(vinyl chloride) (PVC) is the most used biomedical polymer worldwide. PVC is a stable and chemically inert polymer. However, microorganisms can colonize PVC producing biomedical device-associated infections. While surface modifications of PVC can help improve the antimicrobial and antiviral properties, the chemically inert nature of PVC makes those modifications challenging and potentially toxic. In this work, we modified the PVC surface using a derivative riboflavin molecule that was chemically tethered to a plasma-treated PVC surface. Upon a low dosage of blue light, the riboflavin tethered to the PVC surface became photochemically activated, allowing for bacterial biofilm and lentiviral in situ eradication.

摘要

聚氯乙烯（PVC）是全球使用最广泛的生物医学聚合物。PVC是一种稳定且化学惰性的聚合物。然而，微生物可在PVC上定殖，引发与生物医学装置相关的感染。虽然PVC的表面改性有助于改善抗菌和抗病毒性能，但PVC的化学惰性使得这些改性具有挑战性且可能有毒。在这项工作中，我们使用一种化学连接到经等离子体处理的PVC表面的核黄素衍生物分子对PVC表面进行改性。在低剂量蓝光照射下，连接到PVC表面的核黄素发生光化学活化，从而能够原位根除细菌生物膜和慢病毒。